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Bismuth induced encephalopathy caused by tri potassium dicitrato bismuthate in a patient with chronic renal failure.
  1. R J Playford,
  2. C H Matthews,
  3. M J Campbell,
  4. H T Delves,
  5. K K Hla,
  6. H J Hodgson,
  7. J Calam
  1. Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.


    A 68 year old man with a creatinine clearance rate of only 15 ml/min took twice the recommended dose of tripotassium dicitrato bismuthate (TDB) as DeNol liquid; 10 ml qds; a total of 864 mg bismuth daily for two months. Whole blood bismuth concentrations rose to 880 micrograms/l and he developed global cerebral dysfunction with hallucinations, ataxia, and an abnormal EEG. Renal clearance of bismuth rose from 0.24 to 2.4 ml/min when the heavy metal chelator 2-3 dimercapto-1 propane sulphonic acid (DMPS) was given by mouth. Bismuth was measured by a novel method involving inductively coupled plasma source mass spectrometry. Fifty days after stopping TDB, whole blood bismuth concentrations fell to 46 micrograms/l and the patient's EEG returned to normal. His mental function also recovered completely. The case serves as a timely reminder that TDB should not be administered to patients with renal disorders, as stated in the data sheet.

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