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Response to autoimmune enteropathy to cyclosporin A therapy.
  1. I R Sanderson,
  2. A D Phillips,
  3. J Spencer,
  4. J A Walker-Smith
  1. Academic Unit of Paediatric Gastroenterology, Queen Elizabeth Hospital for Children, London.

    Abstract

    Small bowel enteropathies that are associated with an autoimmune process are often resistant to treatment. Two children with autoimmune enteropathy were treated with cyclosporin A for eight months. Both improved, as assessed by growth, small intestinal mucosal morphology, and carbohydrate absorption. Cyclosporin A is useful in the treatment of autoimmune enteropathy. This report also suggests that T cell activation (which is suppressed by cyclosporin A) is important in the pathogenesis of this condition.

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