In an interim analysis of the Benelux trial, no difference in alanine aminotransferase normalisation has been found between the high (6 million units) and standard (3 million units) doses of interferon alfa-2b during the first eight weeks of treatment. The probability of achieving normal alanine aminotransferase activity on at least two successive occasions during treatment is 65% for the standard dose and 73% for the higher dose. Measurement of plasma hepatitis C virus-RNA suggests that hepatitis C virus-RNA negativity after four weeks of treatment is a prerequisite for sustained response to interferon alfa-2b.
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