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Quantitative hepatitis C virus RNA and liver histology in chronic hepatitis C patients treated with interferon alfa.
  1. G Yamada,
  2. M Takahashi,
  3. H Endo,
  4. T Doi,
  5. R Miyamoto,
  6. H Shimomura,
  7. K Yamamoto,
  8. T Tsuji
  1. First Department of Internal Medicine, Okayama University Medical School, Japan.


    Seventy patients with hepatitis C virus (HCV) infection received alpha interferon at doses ranging from 3 to 10 million units (MU) daily for eight weeks, three times weekly for 12-24 weeks, or daily and three times weekly for 12-24 weeks. The efficacy of interferon was closely related to the initial blood HCV-RNA values in that these were lower in those who responded completely and partially compared with non-responders. Continuous reductions in HCV-RNA and improvements in the histology activity index score were seen in those who responded completely. In contrast, most of the partial and non-responders remained HCV-RNA positive.

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