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Alpha interferon treatment of chronic hepatitis C in beta-thalassaemia.
  1. V Di Marco,
  2. O Lo Iacono,
  3. M Capra,
  4. S Grutta,
  5. C Ciaccio,
  6. C Gerardi,
  7. A Maggio,
  8. D Renda,
  9. P Almasio,
  10. R Pisa
  1. Clinica Medica R and Anat Patologica, Ospedale Cervello, Palermo, Sicily, Italy.


    In this open, pilot study, interferon (IFN) alpha-2b seemed effective in the treatment of hepatitis C virus (HCV) infection in patients with beta-thalassaemia. In seven of nine patients who completed the study alanine aminotransferase activities returned to normal, and a completely stable response 24 months after treatment was seen in five. Liver biopsy specimen showed a clear reduction in portal, periportal, and lobular necroinflammation in all five cases. Three patients stopped treatment early because of side effects.

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