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Prevalence of peptic ulcer in Helicobacter pylori positive blood donors.
  1. D Vaira,
  2. M Miglioli,
  3. P Mulè,
  4. J Holton,
  5. M Menegatti,
  6. M Vergura,
  7. G Biasco,
  8. R Conte,
  9. R P Logan,
  10. L Barbara
  1. 1st Medical Clinic, University of Bologna, Italy.

    Abstract

    This study aimed to determine the importance of raised antibodies to Helicobacter pylori in an asymptomatic population. A total of 128 asymptomatic blood donors who were seropositive for H pylori and consented to endoscopy were investigated. These subjects were from a population of 1010 blood donors screened for antibodies to H pylori. A questionnaire was completed to determine if any subjects had complained of symptoms, and they subsequently had endoscopy. Altogether 121 of 128 were positive for H pylori by histology and urease test and/or culture and all 121 had chronic active gastritis on histology. Twenty five of these subjects had peptic ulcer (20 duodenal, five gastric), a further 21 had erosive duodenitis, and two were found to have gastric cancer. H pylori associated peptic ulcer disease and duodenitis occur more frequently than previously recognised and this suggests that H pylori infection, even if asymptomatic, is of far greater clinical relevance than originally thought.

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