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EDITORIAL

  • Aging and the alimentary tract

    • MICHAEL FARTHING,
    • OLIVER JAMES
    Gut 1997;41:4 421 doi:10.1136/gut.41.4.421

Leading articles

  • The aging oesophagus

    • JAN TACK,
    • GASTON VANTRAPPEN
    Gut 1997;41:4 422-424 doi:10.1136/gut.41.4.422

  • The aging stomach: implications for NSAID gastropathy

    • MAKAU LEE,
    • MARK FELDMAN
    Gut 1997;41:4 425-426 doi:10.1136/gut.41.4.425

  • Gastrointestinal surgery in old age: issues of equality and quality

    • D GWYN SEYMOUR
    Gut 1997;41:4 427-429 doi:10.1136/gut.41.4.427

  • Parenchymal liver disease in the elderly

    • O F W JAMES
    Gut 1997;41:4 430-432 doi:10.1136/gut.41.4.430

  • Biliary tract diseases in the elderly: management and outcomes

    • JEROME H SIEGEL,
    • FRANKLIN E KASMIN
    Gut 1997;41:4 433-435 doi:10.1136/gut.41.4.433

REVIEW

  • Hirschsprung’s disease: genetic mutations in mice and men

    • K ROBERTSON,
    • I MASON,
    • S HALL
    Gut 1997;41:4 436-441 doi:10.1136/gut.41.4.436

Helicobacter pylori

  • Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains

    • Y Yamaoka,
    • M Kita,
    • T Kodama,
    • N Sawai,
    • K Kashima,
    • J Imanishi
    Gut 1997;41:4 442-451 doi:10.1136/gut.41.4.442

  • Helicobacter pylori independent chronological change in gastric acid secretion in the Japanese

    • Y Kinoshita,
    • C Kawanami,
    • K Kishi,
    • H Nakata,
    • Y Seino,
    • T Chiba
    Gut 1997;41:4 452-458 doi:10.1136/gut.41.4.452

  • Peptic ulcer bleeding in the elderly: relative roles ofHelicobacter pylori and non-steroidal anti-inflammatory drugs

    • D J E Cullen,
    • G M Hawkey,
    • D C Greenwood,
    • H Humphreys,
    • V Shepherd,
    • R F A Logan,
    • C J Hawkey
    Gut 1997;41:4 459-462 doi:10.1136/gut.41.4.459

  • High prevalence of cytotoxin positive Helicobacter pylori in patients unrelated to the presence of peptic ulcers in Japan

    • K Ogura,
    • F Kanai,
    • S Maeda,
    • H Yoshida,
    • M Ogura,
    • K-H Lan,
    • K Hirota,
    • T Kawabe,
    • Y Shiratori,
    • M Omata
    Gut 1997;41:4 463-468 doi:10.1136/gut.41.4.463

  • Association between genetic polymorphism of the pepsinogen C gene and gastric body ulcer: the genetic predisposition is not associated with Helicobacter pylori infection

    • Y Ohtaki,
    • T Azuma,
    • J Konishi,
    • S Ito,
    • M Kuriyama
    Gut 1997;41:4 469-474 doi:10.1136/gut.41.4.469

Small bowel

  • Prospective evaluation of protein bound vitamin B12(cobalamin) malabsorption in the elderly using trout flesh labelled in vivo with 57Co-cobalamin

    • I Aimone-Gastin,
    • H Pierson,
    • C Jeandel,
    • J P Bronowicki,
    • F Plénat,
    • D Lambert,
    • F Nabet-Belleville,
    • J L Guéant
    Gut 1997;41:4 475-479 doi:10.1136/gut.41.4.475

Inflammatory bowel disease

  • Incidence of Crohn’s disease in Stockholm County 1955–1989

    • A Lapidus,
    • O Bernell,
    • G Hellers,
    • P-G Persson,
    • R Löfberg
    Gut 1997;41:4 480-486 doi:10.1136/gut.41.4.480

  • Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor α production in trinitrobenzene sulphonic acid induced colitis

    • C K Ameho,
    • A A Adjei,
    • E K Harrison,
    • K Takeshita,
    • T Morioka,
    • Y Arakaki,
    • E Ito,
    • I Suzuki,
    • A D Kulkarni,
    • A Kawajiri,
    • S Yamamoto
    Gut 1997;41:4 487-493 doi:10.1136/gut.41.4.487

Motility and visceral sensation

  • Acute hyperglycaemia affects anorectal motor and sensory function in normal subjects

    • A Russo,
    • W M Sun,
    • Y Sattawatthamrong,
    • R Fraser,
    • M Horowitz,
    • J M Andrews,
    • N W Read
    Gut 1997;41:4 494-499 doi:10.1136/gut.41.4.494

  • Role of cholecystokinin in the regulation of liquid gastric emptying and gastric motility in humans: studies with the CCK antagonist loxiglumide

    • W Schwizer,
    • J Borovicka,
    • P Kunz,
    • R Fraser,
    • C Kreiss,
    • M D’Amato,
    • G Crelier,
    • P Boesiger,
    • M Fried
    Gut 1997;41:4 500-504 doi:10.1136/gut.41.4.500

  • Evidence for two distinct perceptual alterations in irritable bowel syndrome

    • B D Naliboff,
    • J Munakata,
    • S Fullerton,
    • R H Gracely,
    • A Kodner,
    • F Harraf,
    • E A Mayer
    Gut 1997;41:4 505-512 doi:10.1136/gut.41.4.505

Cancer

  • Gastric cancer below the age of 55: implications for screening patients with uncomplicated dyspepsia

    • J Christie,
    • N A Shepherd,
    • B W Codling,
    • R M Valori
    Gut 1997;41:4 513-517 doi:10.1136/gut.41.4.513

  • Severe upper gastrointestinal polyposis associated with sparse colonic polyposis in a familial adenomatous polyposis family with an APC mutation at codon 1520

    • B A Leggett,
    • J P Young,
    • K Biden,
    • R L Buttenshaw,
    • N Knight,
    • A E Cowen
    Gut 1997;41:4 518-521 doi:10.1136/gut.41.4.518

  • Is there an excess risk for colorectal cancer in patients with ulcerative colitis and concomitant primary sclerosing cholangitis? A population based study

    • D Kornfeld,
    • A Ekbom,
    • T Ihre
    Gut 1997;41:4 522-525 doi:10.1136/gut.41.4.522

Liver

  • A multicentre randomised trial comparing octreotide and injection sclerotherapy in the management and outcome of acute variceal haemorrhage

    • S A Jenkins,
    • R Shields,
    • M Davies,
    • E Elias,
    • A J Turnbull,
    • M F Bassendine,
    • O F W James,
    • J P Iredale,
    • S K Vyas,
    • M J P Arthur,
    • A N Kingsnorth,
    • R Sutton
    Gut 1997;41:4 526-533 doi:10.1136/gut.41.4.526

  • Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury

    • V A J Maria,
    • R M M Victorino
    Gut 1997;41:4 534-540 doi:10.1136/gut.41.4.534

Biliary tract

  • Endoscopic papillary balloon dilatation may preserve sphincter of Oddi function after common bile duct stone management: evaluation from the viewpoint of endoscopic manometry

    • H Sato,
    • T Kodama,
    • J Takaaki,
    • Y Tatsumi,
    • T Maeda,
    • S Fujita,
    • Y Fukui,
    • H Ogasawara,
    • S Mitsufuji
    Gut 1997;41:4 541-544 doi:10.1136/gut.41.4.541

  • Are complications of endoscopic sphincterotomy age related?

    • G T Deans,
    • P Sedman,
    • D F Martin,
    • C M S Royston,
    • C K Leow,
    • W E G Thomas,
    • W A Brough
    Gut 1997;41:4 545-548 doi:10.1136/gut.41.4.545

Molecular gastroenterology

  • Liposome mediated gene transfer into the rat oesophagus

    • R M Schmid,
    • H Weidenbach,
    • G F Draenert,
    • S Liptay,
    • H Lührs,
    • G Adler
    Gut 1997;41:4 549-556 doi:10.1136/gut.41.4.549

CASE REPORT

  • Monozygotic twins with Crohn’s disease and ulcerative colitis: a unique case report

    • N P Breslin,
    • A Todd,
    • C Kilgallen,
    • C O’Morain
    Gut 1997;41:4 557-560 doi:10.1136/gut.41.4.557

  • Primary ileal villous atrophy is often associated with microscopic colitis

    • P Marteau,
    • A Lavergne-Slove,
    • M Lemann,
    • Y Bouhnik,
    • P Bertheau,
    • H Becheur,
    • A Galian,
    • J C Rambaud
    Gut 1997;41:4 561-564 doi:10.1136/gut.41.4.561

SCIENCE ALERT

  • Tissue transglutaminase as the autoantigen of coeliac disease

    • MARKKU MÄKI
    Gut 1997;41:4 565-566 doi:10.1136/gut.41.4.565

Commentaries

  • Opening the doors of perception in the irritable bowel syndrome

    • LESLEY A HOUGHTON,
    • P J WHORWELL
    Gut 1997;41:4 567-568 doi:10.1136/gut.41.4.567

  • “Déjà vu all over again”: (Yogi Berra)

    • PETER B ERNST
    Gut 1997;41:4 569-570 doi:10.1136/gut.41.4.569

  • Ulcerative colitis: sclerosing cholangitis today, cancer tomorrow?

    • ULRIKA BROOMÉ,
    • R W CHAPMAN
    Gut 1997;41:4 571-572 doi:10.1136/gut.41.4.571

  • Sense and sensitisation: in vitro testing for hepatotoxic drug hypersensitivity

    • JEREMY WOODWARD,
    • JAMES NEUBERGER
    Gut 1997;41:4 573-574 doi:10.1136/gut.41.4.573

  • The aging stomach or the stomachs of the ages

    • ADRIAN LEE,
    • SANDER VELDHUYZEN VAN ZANTEN
    Gut 1997;41:4 575-576 doi:10.1136/gut.41.4.575

LETTERS TO THE EDITOR

  • Endoscopic findings and clinical patterns are not useful for distinguishing low from high grade gastric MALT lymphoma

    • ANTONIO TURSI,
    • GIOVANNI CAMMAROTA,
    • ALFREDO PAPA,
    • GIUSEPPE FEDELI,
    • GIOVANNI GASBARRINI
    1. Commentator:
      • B G TAAL,
      • H BOOT,
      • and D DE JONG
    Gut 1997;41:4 577 doi:10.1136/gut.41.4.577

  • Natural history of polypoid lesions of the gall bladder

    • E KYRIACOU
    1. Commentator:
      • CHIFUMI SATO
    Gut 1997;41:4 577-580 doi:10.1136/gut.41.4.577a

  • Polypoid lesions of the gall bladder

    • C D JOHNSON
    1. Commentator:
      • CHIFUMI SATO
    Gut 1997;41:4 577 doi:10.1136/gut.41.4.577b

  • Bone mineral density in Crohn’s disease

    • F J COWAN,
    • J W GREGORY,
    • H R JENKINS
    1. Commentator:
      • J JAHNSEN,
      • J A FALCH,
      • and E AADLAND
    Gut 1997;41:4 577 doi:10.1136/gut.41.4.577c

  • Incidence of persistent symptoms after laparoscopic cholecystectomy

    • P W PLAISIER
    1. Commentator:
      • W LUMAN and
      • K R PALMER
    Gut 1997;41:4 577 doi:10.1136/gut.41.4.577d

  • An exceptional high concentration of serum CA 19.9 in a patient with alcoholic liver disease

    • E DE GOEDE,
    • S H YAP
    Gut 1997;41:4 577 doi:10.1136/gut.41.4.e577

BOOK REVIEW

  • Inflammatory Bowel Diseases

    • ROSE MECHAN
    Gut 1997;41:4 577 doi:10.1136/gut.41.4.577f

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