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Transcatheter coil embolotherapy: a safe and effective option for major colonic haemorrhage
  1. A A Nicholsona,
  2. D F Ettlesa,
  3. J E Hartleyb,
  4. I Curzona,
  5. P W R Leeb,
  6. G S Duthieb,
  7. J RT Monsonb
  1. aDepartment of Radiology, Hull Royal Infirmary, East Yorkshire, bUniversity of Hull, Academic Surgical Unit, Castle Hill Hospital, Cottingham, East Yorkshire, UK
  1. Dr A A Nicholson, Department of Radiology, Hull Royal Infirmary, Anlaby Road, Hull, East Yorkshire HU3 2JZ, UK.

Abstract

Background—The management of major colonic bleeding is problematic. A proportion of patients require emergency surgery which is associated with high morbidity and mortality. Percutaneous embolotherapy, previously considered a high risk procedure in the colon, may provide an alternative treatment in this group of patients.

Aims—To assess the safety and efficacy of embolotherapy in the treatment of life threatening colonic haemorrhage.

Patients and methods—Thirty eight patients with fresh haemorrhage per rectum were referred for surgery because of failed conservative treatment. All underwent angiography; in 14 a bleeding site or vascular abnormality was detected. A coaxial catheter was directed to the most distal bleeding artery and this was embolised with platinum coils.

Results—Detection of a bleeding site correlated with haemodynamic stability at the time of angiography (r=1 for a systolic blood pressure less than 100 mm Hg). Bleeding sites or vascular abnormalities were detected and embolised in 14 patients (37%). In 12/14 there was immediate and sustained haemodynamic improvement; two continued to bleed and required emergency hemicolectomy (14%). Three developed ischaemic complications (21.4%); these were managed conservatively and required no intervention. The 30 day mortality was 7.1% in the embolotherapy group and 10.5% in the overall group of 38 patients.

Conclusion—Colonic embolotherapy for life threatening haemorrhage is an effective, relatively safe procedure with a low incidence of major complications. Its use depends on the identification of a focal bleeding point or vascular abnormality, which in turn depends on the haemodynamic stability of the patient at the time of angiography.

  • colonic haemorrhage
  • embolisation
  • angiography
  • angiodysplasia
  • diverticular disease

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Colonic haemorrhage which is severe enough to warrant surgical intervention is an uncommon event; it is however most frequently encountered in elderly patients who tolerate hypovolaemia poorly. Such patients pose major diagnostic and management problems. In particular the need to resuscitate the patient must be balanced against the need to identify the source of bleeding. The reported mortality following emergency colonic resection for bleeding ranges from 10 to 36%.1 2 Some surgeons perform right hemicolectomy when the bleeding source is occult,3 and accept they will be wrong in a significant number of cases. Others perform a total colectomy with an attendant increase in mortality. The most common cause of bleeding in the colon was thought to be diverticular disease but postmortem studies have suggested that the source is likely to be from small angiodysplasias which are often associated. Angiography is the most accurate diagnostic test for determining the bleeding source.4 Logically it will be most effective when the patient is bleeding.

Various studies have reported positive findings in approximately 43%4 to 87%5 of patients with acute massive lower gastrointestinal haemorrhage when actively bleeding. In contrast, a source of bleeding is identified in only 20% of patients who are not actively bleeding.6 Emergency angiography is therefore best performed when the blood pressure is falling and the pulse rate rising despite volume replacement. As 95% of lower gastrointestinal bleeds settle with conservative measures true emergency angiography should be reserved for patients who are destined for laparotomy and colectomy because of profound haemodynamic instability. In practice a significant number of these patients will have temporarily stopped bleeding prior to angiography despite best efforts to free laboratory time and staff. However the development of sophisticated catheters and guide wires means that selective and superselective angiography is relatively easy and quick. This increases the yield of positive findings.

The development of transcatheter therapy for colonic haemorrhage was a logical extension of diagnostic angiography, given the desirability of avoiding emergency surgery. Transcatheter embolisation provides an attractive alternative because of the immediate haemostasis that can be achieved. As long ago as 1977, Goldberger and Bookstein advocated transcatheter embolisation7 but by 1982 they and others were reporting significant colonic infarction.8 The technique subsequently fell into disrepute. However, analysis of the early data suggests that the 7F catheters and non-steerable wires used at that time only allowed embolisation of marginal arteries. Thus large areas of colon were rendered ischaemic. The development of hydrophilic steerable catheters and guide wires, as well as coaxial systems as small as 2F, allows the delivery of small embolisation coils and alcohol coated particles to the bleeding point at the mucosal surface. Thus only small focal areas of colon are infarcted.

Patients and methods

Over a 24 month period from April 1995, 38 patients (18 men and 20 women; mean age 73 years, range 57–87) referred to Vascular Radiology for emergency mesenteric angiography for colorectal bleeding were considered for transcatheter embolotherapy. All patients were undergoing angiography in order to localise the source of haemorrhage prior to emergency colonic resection. Such patients were therefore actively bleeding at the time of referral, had failed to respond to conservative management, and were haemodynamically unstable despite continued transfusion. In practice only 17 were actively bleeding at the time of angiography, shown by blood pressure and pulse measurement before and during the procedure.

Initial inferior and superior mesenteric angiography was performed via a femoral approach using 5-French gauge femorovisceral catheters. Once the bleeding point was identified a 2.2-French gauge coaxial Tracker-18 catheter (Terumo, Piscataway, New Jersey, USA) was passed over a torquable seeker guide wire, down the femorovisceral catheter, to the bleeding site (fig 1). Superselective angiography was used to confirm the position of the catheter in relation to the bleeding point. Appropriate size platinum microcoils were then advanced down the catheter into the bleeding vessel using a pusher wire. Final superselective angiography confirmed coil position and cessation of bleeding (fig 2).

Figure 1

Digital subtraction angiography of the superior mesenteric artery, with superselective cannulation of a caecal branch of the ileocolic artery, showing haemorrhage into the caecal pole.

Figure 2

Introduction of a distal coil resulting in almost instantaneous arrest of haemorrhage.

Results

Figure 3 shows the results of angiography. Of the 38 patients in the study, 17 were actively bleeding at the time of angiography as evidenced by hypotension, tachycardia (despite transfusion), and fresh blood per rectum. The appearance of contrast extravasation correlated perfectly with a systolic blood pressure of less than 100 mm Hg (r=1). This appearance, indicating a colonic bleeding point, was identified and embolised in 13 (76.5%). Of the other four, two were bleeding from the small bowel and two were bleeding from haemorrhoids; they are therefore considered no further. A vascular abnormality, a rectal angiodysplasia,9 was seen in only one of the 21 haemodynamically stable patients at the time of angiography (4.8%), although 15 of the remaining 20 subsequently underwent elective colonic resection. Six microcoils were inserted to obliterate this as multiple proctoscopies and sigmoidoscopies had failed to establish the diagnosis.

Figure 3

Results of angiography in patients with major colonic haemorrhage, April 1995 to April 1997. SMA, superior mesenteric artery; IMA, inferior mesenteric artery.

The mean systolic blood pressure at the time of angiography was 76 mm Hg (in two patients this was unrecordable), with a mean haemoglobin of 7.1 g/dl (range 4–10 g/dl) despite a mean transfusion volume of 6 units (range 2–8 units). Table 1 presents the clinical details, angiography findings, and details and results of embolisation.

Table 1

Relevant clinical details and outcome of patients with major colonic haemorrhage treated by transcatheter coil embolotherapy

In 11 patients a single source of haemorrhage was identified. One patient was bleeding from two discrete sites in the right colon, and a further patient was bleeding diffusely from the left colon. Embolisation achieved haemostasis in 12 of the 14 patients, and in four of these only a single coil was required.

Two patients continued to bleed. One did so from a diffuse left sided Crohn’s colitis. Multiple coils were placed in the marginal artery in the hope of achieving a degree of haemodynamic stability. The patient died from a postmortem examination confirmed cerebrovascular event 48 hours after emergency colonic resection. Angiography showed contrast extravasation at the hepatic flexure in a second patient. This was successfully embolised but the patient rebled at 24 hours. Repeat angiography failed to show the source of the recurrent bleed. Pathology revealed a hepatic flexure haemangioma following emergency right hemicolectomy.

A single patient had a persistent but haemodynamically insignificant bleed following embolisation. Sigmoidoscopy confirmed the angiographic diagnosis of a solitary rectal ulcer. This was successfully managed by insertion of an adrenaline soaked pack and formation of a covering stoma. The patient died of bronchopneumonia eight weeks later.

A second patient, having undergone successful embolotherapy for a middle colic arterial haemorrhage, later underwent elective right hemicolectomy for diverticular disease.

There were three ischaemic complications. In the first of these two areas of contrast extravasation were seen. Single coils were inserted at the hepatic flexure and caecal pole to good haemostatic effect (fig4). However the first coil, in the distal middle colic artery, was inadvertently placed more proximally than would be considered ideal. Routine double contrast barium enema investigation subsequently revealed a smooth stricture at the hepatic flexure (fig 5), the ischaemic nature of which was confirmed by colonoscopic biopsy. The patient remains asymptomatic 18 months later. The second ischaemic complication arose in a patient on dialysis with a life threatening splenic flexure haemorrhage. The marginal artery at this site was embolised because of difficulty in negotiating the “end artery”. Clinical signs of ischaemic colitis developed six hours later. In the absence of peritonism or systemic upset, the patient was managed conservatively and settled over the ensuing 48 hours. Colonoscopy 72 hours post-angiography revealed a 10 cm segment of mucosal necrosis at the splenic flexure. The patient’s further recovery was uneventful and she remains well 14 months later.

Figure 4

Angiography indicated bleeding sites at the hepatic flexure and caecal pole. The hepatic flexure coil was placed too close to the marginal artery. Though haemorrhage ceased immediately, an occult ischaemic stricture developed at the site (see fig 5). The caecal pole coils produced immediate haemostasis with no complications.

Figure 5

Ischaemic stricture at the hepatic flexure following coil embolisation in the middle colic artery territory (see fig 4).

The patient with rectal angiodysplasia had a two year history of daily rectal bleeding prior to the life threatening bleed requiring emergency treatment. He had been fully investigated, apart from angiography, during several previous admissions. Following embolisation there was immediate haemostasis. He had no further bleeding for four months but then developed intermittent minor blood loss and slight difficulty at defecation. Examination revealed a moderate rectal stenosis which would admit a rigid sigmoidoscope. At present this has been treated conservatively.

Discussion

Since transcatheter embolisation was first performed by Newton and Adams in 196710 modifications of the technique have been used at numerous sites throughout the body, using a variety of embolic materials including gelfoam, autologous blood, and steel coils.11-13 Embolisation for colonic haemorrhage was first performed by Goldberger and Bookstein in 1977.7However, despite early successes,14 15 this approach has not been widely embraced because of reports of colonic ischaemia and infarction.8 16 Some degree of distal ischaemia is the inevitable consequence of embolisation. Technical developments over the past five years have allowed us to re-evaluate the potential of colonic embolotherapy. We believe that the particular value of the coaxial tracker catheter system lies in its ability to catheterise superselectively the “radiological end arteries” distally in the mesenteric arcade beyond the marginal artery. Platinum microcoils can then be placed extremely accurately in order to produce permanent occlusion of these vessels within minutes.17 These coils also have the advantage of avoiding the particulate reflux which is sometimes seen with other embolic materials. It is perhaps significant that early reports of post-embolisation ischaemia have followed procedures in which the secondary branches of the superior mesenteric artery were not selectively catheterised.8 In our experience significant ischaemia was only encountered when vessels proximal to the “end artery” were embolised—by either accident or design. We were perhaps fortunate in being able to manage both such patients conservatively. With the benefit of hindsight, if the “radiological end artery” cannot be catheterised, vasopressin infusion may be preferable to embolisation.

In the series presented here coil embolotherapy proved strikingly effective in the control of haemorrhage. This preliminary experience was deliberately limited to a highly selected group of patients who were haemodynamically unstable despite adequate attempts at resuscitation, and were destined for emergency laparotomy should embolisation fail to achieve haemostasis. We would therefore suggest that embolisation in fact saved 12 of the 14 patients from emergency colonic resection.

The patient in the embolotherapy group who died did so from a cerebrovascular accident following surgery. This was the only 30 day mortality in this group. There were four deaths in the 30 day period following angiography in the overall group of 38 patients. This difference was not statistically significant but there is a clear trend. The remaining patients are well after 3–20 months of follow up. A final diagnosis of diverticular disease was made in the majority of patients though this should be viewed with caution in the light of current thinking and also because the majority were bleeding from the right colon. Accurate diagnosis of the aetiology of colonic bleeding in the acute situation, particularly with relatively low resolution digital subtraction angiography, may be difficult. Published experience would suggest that most bleeding from the right colon is the result of angiodysplasia even in the presence of diverticulosis.18 19

Although the number of patients is small, their outcome compares favourably with reported success rates for vasopressin infusion which range from 31 to 91% for cessation of lower gastrointestinal haemorrhage.20-23 However embolisation, if ischaemic problems are avoided, has potential advantages over vasopressin infusion by virtue of the almost instant control of haemorrhage. In addition, major and minor morbidity rates of up to 40% have been reported following intra-arterial vasopressin infusion for colonic bleeding,24 with local and systemic ischaemia,25 reductions in cardiac output, hypertension, and cardiac arrhythmias all being documented.22

Clearly the decision whether to embolise or not depends on a number of factors. It should not be used in the patient who has not had a trial of conservative treatment. Angiodysplasias and other vascular abnormalities are rare. It is therefore important to see contrast extravasation. This will only happen if active bleeding is present at the time of angiography. The need to resuscitate the patient has to be weighed against the need to find the bleeding site and embolise it. If a vascular abnormality is seen the decision to embolise depends on its size and the number of arterial tributaries. It should be noted that embolisation of large angiodysplasias is likely to produce temporary cessation of bleeding at best as these lesions invariably have contributions from arteries that are too small to be seen at angiography but grow following occlusion of larger vessels. However embolisation may convert an emergency case into an elective one on a patient haemodynamically better able to withstand surgery. When rectal bleeding is seen careful consideration of other options has to be made. Endoscopic therapy may be effective. However if the bleeding is continuous and obscures the view of the operator or if numerous sigmoidoscopies have failed to show the abnormality then embolisation should be used.

The results of this series confirm the technical feasibility of transcatheter embolotherapy with platinum microcoils for the emergency control of significant colonic haemorrhage. With meticulous attention to technique, paying particular credence to the importance of superselective embolisation of “radiological end arteries”, colonic ischaemia and infarction seem to be avoidable complications. Given appropriate levels of vascular radiological expertise and facilities, coil embolisation of active colonic bleeding can, in selected patients, obviate the requirement for emergency colonic resection. In view of the potential for procedure related complications these techniques should, at present, be reserved for use in actively bleeding patients who will require surgery should embolisation be unsuccessful.

References

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