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Gut 1998;43:575-577 doi:10.1136/gut.43.4.575
  • 28, 40, 156

Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis

  1. K Ohbaa,
  2. K Omagaria,
  3. T Nakamuraa,
  4. N Ikunoa,
  5. S Saekia,
  6. I Matsuoa,
  7. H Kinoshitaa,
  8. J Masudaa,
  9. H Hazamaa,
  10. I Sakamotob,
  11. S Kohnoa
  1. aSecond Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852–8501, Japan, bDepartment of Radiology
  1. Dr K Omagari.
  • Accepted 18 February 1998

Abstract

Spontaneous regression of hepatocellular carcinoma is a rare phenomenon. Abscopal regression of tumours resulting from the effect of irradiation of a tissue on a remote non-irradiated tissue is also rare. The case of a 76 year old Japanese man with hepatocellular carcinoma that regressed after radiotherapy for thoracic vertebral bone metastasis is described. Serum levels of tumour necrosis factor-α increased after radiotherapy. The findings suggests that such abscopal related regression may be associated with host immune response, involving cytokines such as tumour necrosis factor-α.

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