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Gut 43:744-746 doi:10.1136/gut.43.6.744
  • CLINICAL ALERT

Omeprazole in the treatment of ulcers induced by NSAIDs

Omeprazole (OM) v ranitidine for ulcers associated with long term non-steroidal anti-inflammatory drug use1-2-150

Outcomes OM 20 mg/day OM 40 mg/day Ranitidine 300 mg/day RBI (95% CI) NNT (CI)
Healing at 8 weeks 80% 63% 27% (12 to 46) 6 (4 to 13)
Healing at 8 weeks 79% 63% 25% (10 to 44) 7 (4 to 16)
Remission at 6 months 72% 59% 22% (6 to 40) 8 (5 to 27)
  • 1-2-150 RBI = proportional increase in rates of good outcomes between groups; NNT = number of patients who must receive omeprazole to achieve 1 additional good outcome.

  • Note: the material presented in the table was not in the orginal article on which the commentary is based.

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