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Gut 44:822-825 doi:10.1136/gut.44.6.822
  • Cancer

Molecular screening of patients with long standing extensive ulcerative colitis: detection of p53 and Ki-ras mutations by single strand conformation polymorphism analysis and differential hybridisation in colonic lavage fluid

Table 2

Correlation of p53 and Ki-ras mutations with patient characteristics

Number of patients p53 mutations Ki-ras mutations Total
Disease duration (years)
 7–9 13 1 0 1/13
 10–15 10 3 1 4/10
 >15 8 0 1 1/8
Severity of disease
 Mild 3 0 0 0 / 3
 Moderate 13 3 2 5/13
 Severe 15 1 0 1/15
Morphological disease activity
 No relevant activity 13 2 1 3 / 13
 Moderate 15 2 1 3/15
 Severe 3 0 0 0/3

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