Article Text
Abstract
BACKGROUND Hyperammonaemia is a pathogenetic factor for hepatic encephalopathy that may be augmented after a transjugular intrahepatic portosystemic shunt (TIPS). Experimental data suggest that hyperammonaemia may be caused to a large extent by metabolism of small intestinal enterocytes rather than colonic bacteria.
AIMS To evaluate if ammonia release and glutamine metabolism by small intestinal mucosa contribute to hyperammonaemia in vivo in patients with liver cirrhosis.
METHODS Using TIPS to examine mesenteric venous blood, we measured mesenteric venous-arterial concentration differences in ammonia and glutamine in patients with liver cirrhosis before, during, and after enteral (n=8) or parenteral (n=8) isonitrogenous infusion of a glutamine containing amino acid solution.
RESULTS During enteral nutrient infusion, ammonia release increased rapidly compared with the post-absorptive state (65 (58–73) v 107 (95–119) μmol/l after 15 min; mean (95% confidence interval)) in contrast with parenteral infusion (50 (41–59)v 62 (47–77) μmol/l). This resulted in a higher portal ammonia load (29 (21–36) v 14 (8–21) mmol/l/240 minutes) and a higher degree of systemic hyperammonaemia (14 (11–17) v 9 (6–12) mmol/l/240 minutes) during enteral than parenteral infusion. The mesenteric venous-arterial concentration difference in glutamine changed from net uptake to release at the end of the enteral infusion period (−100 (−58 to −141) v 31 (−47–110) μmol/l) with no change during parenteral nutrition.
CONCLUSIONS These data suggest that small intestinal metabolism contributes to post-feeding hyperammonaemia in patients with cirrhosis. When artificial nutrition is required, parenteral nutrition may be superior to enteral nutrition in patients with portosystemic shunting because of the lower degree of systemic hyperammonaemia.
- hepatic encephalopathy
- intestinal metabolism
- ammonia
- glutamine
- enteral nutrition
- parenteral nutrition
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Footnotes
- Abbreviations used in this paper:
- AA
- amino acid
- ALD
- alcoholic liver disease
- AUC
- area under the curve
- PBC
- primary biliary cirrhosis
- SMV
- superior mesenteric vein
- TIPS
- transjugular intrahepatic portosystemic shunt