Article Text
Abstract
Modern medicine has had a considerable impact on mortality rates for serious illness. Many chronic diseases which have previously been associated with an increased mortality now have survival rates approaching those of the background population. However, chronic diseases such as cancer, chronic pain syndromes, and chronic inflammatory conditions impose a considerable burden on families, the health care system, and society. Health related quality of life (HRQOL) is a concept that has developed from the need to estimate the impact of such chronic diseases. HRQOL measurement is a conceptual framework which attempts to predict daily function and well being based on subjective attitudes and experiences of physical, social, and emotional health. It has been evaluated predominantly from the patient's viewpoint as proxy respondents appear to underestimate the full effect of chronic illness on functional status. Measuring HRQOL in clinical research is most frequently undertaken using multi-item questionnaires to estimate daily function. Factors which affect HRQOL can be broadly classed as disease related and disease independent. The use of different assessment techniques permits comparisons between and within disorders. Generic and disease specific instruments used together enhance the ability to direct treatment for individuals and patient populations. Psychometrically sound questionnaires must be used. However, the type of instrument and research methods adopted depend on the question of interest. We have attempted to catalogue and critically assess the disease specific instruments used in the assessment of chronic gastrointestinal disease.
Abbreviations used in this paper
- HRQOL
- health related quality of life
- QOL
- quality of life
- IBD
- inflammatory bowel disease
- GORD
- gastro-oesophageal reflux disease
- NUD
- non-ulcer dyspepsia
- IBS
- irritable bowel syndrome
- CDAI
- Crohn's disease activity index
- SF
- short form
- SIP
- sickness impact profile
- PGWB
- psychological general well being
- GID
- gastrointestinal disorder
- GI
- gastrointestinal
- GIQLI
- gastrointestinal quality of life index
- ICC
- intraclass correlation coefficient
- GSRS
- gastrointestinal symptom rating scale
- PUD
- peptic ulcer disease
- GORQ
- gastro-oesophageal reflux questionnaire
- MOS
- medical outcomes study
- HBQOL
- heartburn quality of Life
- QPD
- quality of life in peptic disease
- FDDQL
- functional digestive disorders quality of life questionnaire
- DU
- duodenal ulcer
- QOLRAD
- quality of life in reflux and dyspepsia
- QLDUP
- quality of life in duodenal ulcer patients
- HPAG
- Helicobacter pylori associated gastritis
- SCL90-R
- symptom checklist
- IBSQ
- irritable bowel syndrome questionnaire
- RFIPC
- rating form of inflammatory bowel disease patient concerns
- UC
- ulcerative colitis
- CD
- Crohn's disease
- IBDQ
- inflammatory bowel disease questionnaire
- STAI
- state-trait anxiety inventory
- NTC
- normal transit constipation
- STC
- slow transit constipation
- EORTC QLQ-C30
- European Organisation for Research and Treatment of Cancer core quality of life questionnaire
- TG
- total gastrectomy
- SG
- subtotal gastrectomy
- TG+R
- total gastrectomy plus gastric reconstruction
- RSC
- Rotterdam symptom checklist
- HPN
- home parenteral nutrition
- QALY
- quality adjusted life year
- CLDQ
- chronic liver disease questionnaire
- HCV
- hepatitis C virus
- HBV
- hepatitis B virus
- IFN
- interferon
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Abbreviations used in this paper
- HRQOL
- health related quality of life
- QOL
- quality of life
- IBD
- inflammatory bowel disease
- GORD
- gastro-oesophageal reflux disease
- NUD
- non-ulcer dyspepsia
- IBS
- irritable bowel syndrome
- CDAI
- Crohn's disease activity index
- SF
- short form
- SIP
- sickness impact profile
- PGWB
- psychological general well being
- GID
- gastrointestinal disorder
- GI
- gastrointestinal
- GIQLI
- gastrointestinal quality of life index
- ICC
- intraclass correlation coefficient
- GSRS
- gastrointestinal symptom rating scale
- PUD
- peptic ulcer disease
- GORQ
- gastro-oesophageal reflux questionnaire
- MOS
- medical outcomes study
- HBQOL
- heartburn quality of Life
- QPD
- quality of life in peptic disease
- FDDQL
- functional digestive disorders quality of life questionnaire
- DU
- duodenal ulcer
- QOLRAD
- quality of life in reflux and dyspepsia
- QLDUP
- quality of life in duodenal ulcer patients
- HPAG
- Helicobacter pylori associated gastritis
- SCL90-R
- symptom checklist
- IBSQ
- irritable bowel syndrome questionnaire
- RFIPC
- rating form of inflammatory bowel disease patient concerns
- UC
- ulcerative colitis
- CD
- Crohn's disease
- IBDQ
- inflammatory bowel disease questionnaire
- STAI
- state-trait anxiety inventory
- NTC
- normal transit constipation
- STC
- slow transit constipation
- EORTC QLQ-C30
- European Organisation for Research and Treatment of Cancer core quality of life questionnaire
- TG
- total gastrectomy
- SG
- subtotal gastrectomy
- TG+R
- total gastrectomy plus gastric reconstruction
- RSC
- Rotterdam symptom checklist
- HPN
- home parenteral nutrition
- QALY
- quality adjusted life year
- CLDQ
- chronic liver disease questionnaire
- HCV
- hepatitis C virus
- HBV
- hepatitis B virus
- IFN
- interferon