Perceptual responses in patients with inflammatory and functional bowel disease
- L Changa,b,
- J Munakataa,
- E A Mayera,
- M J Schmulsona,
- T D Johnsonc,
- C N Bernsteind,
- L Sabaa,
- B Naliboffa,
- P A Antona,
- K Matina
- aUCLA/CURE Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA, bHarbor-UCLA Inflammatory Bowel Disease Center, Harbor-UCLA Medical Center, Torrance, California, USA, cDepartment of Biomathematics, UCLA School of Medicine, Los Angeles, California, USA, dDepartment of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
- Dr L Chang, UCLA/CURE Neuroenteric Disease Program, West Los Angeles VA Medical Center, Building 115, Room 223, Los Angeles, CA 90073, USA. Email:linchang{at}ucla.edu
- Accepted 4 April 2000
Abstract
BACKGROUND AND AIMS Enhanced visceral sensitivity following a transient inflammatory process in the gut has been postulated as an aetiological mechanism of irritable bowel syndrome (IBS). In this study we compared perceptual responses to rectosigmoid distension in patients with mild chronic inflammation of the rectum (ulcerative colitis (UC)) and patients without mucosal inflammation (IBS) to determine if chronic low grade mucosal inflammation may be a plausible explanation for rectosigmoid hypersensitivity reported in both IBS and UC patients.
METHODS UC disease activity was quantified using activity index scores. Perception thresholds for discomfort during rectosigmoid distension were compared between 11 UC patients with quiescent or mild disease activity, 18 IBS patients, and 13 healthy controls.
RESULTS Although UC activity index scores negatively correlated with perceptual thresholds for discomfort (r=−0.76, p=0.016), UC patients had higher discomfort thresholds compared with IBS patients and controls before (p=0.02) and after (p<0.001) a noxious sigmoid conditioning stimulus.
CONCLUSIONS Rectal perception was attenuated in UC but enhanced in IBS. In chronic mild inflammation, activation of antinociceptive mechanisms may prevent the development of visceral hyperalgesia. Low grade mucosal inflammation alone is unlikely to be responsible for symptoms in functional gastrointestinal disorders.
Footnotes
- Abbreviations used in this paper:
- IBS
- irritable bowel syndrome
- UC
- ulcerative colitis
- AI
- activity index
- DAI
- disease activity index
- TNBS
- trinitrobenzene sulphonic acid
