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Gut 48:28-33 doi:10.1136/gut.48.1.28
  • Nutrition

Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial

Table 4

Effect of treatment on diarrhoea in the glutamine and placebo groups

Glutamine Placebo p Value4-150
All patients (n) 29 33
 Duration (mean (SD) days)  1.5 (2.4)  2.8 (3.0) 0.07
 AUC (mean (SD))  1.9 (3.1)  4.5 (5.9) 0.09
 Loperamide (mean (SD) No of cps)  0.4 (1.1)  2.6 (3.5) 0.002
Only patients with diarrhoea (n) 12 19
 Duration (mean (SD) days)  3.7 (2.5)  4.9 (2.3) 0.09
 AUC (mean (SD))  4.6 (3.2)  7.8 (6.0) 0.14
 Loperamide (mean (SD) No of cps)  0.9 (1.7)  4.6 (3.6) 0.0006
  • 4-150 Mann-Whitney test.

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