Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease

R N Cunliffe; F R A J Rose; J Keyte; L Abberley; W C Chan; Y R Mahida

doi:10.1136/gut.48.2.176

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Inflammatory bowel disease

Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease

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	Abstract	Full	Pdf
Jan 2001	53	135	58
Feb 2001	37	98	38
Mar 2001	7	48	34
Apr 2001	8	33	29
May 2001	4	27	10
Jun 2001	2	10	2
Jul 2001	1	21	10
Aug 2001	2	21	6
Sep 2001	1	14	10
Oct 2001	0	16	5
Nov 2001	3	20	6
Dec 2001	3	13	1
Jan 2002	4	15	5
Feb 2002	2	18	5
Mar 2002	2	10	2
Apr 2002	5	27	14
May 2002	4	21	7
Jun 2002	0	9	3
Jul 2002	4	21	14
Aug 2002	2	14	6
Sep 2002	1	23	8
Oct 2002	0	19	9
Nov 2002	4	7	3
Dec 2002	2	10	4
Jan 2003	0	16	5
Feb 2003	3	11	6
Mar 2003	3	19	3
Apr 2003	7	18	6
May 2003	5	16	15
Jun 2003	1	30	17
Jul 2003	8	33	8
Aug 2003	7	14	4
Sep 2003	20	12	4
Oct 2003	17	28	17
Nov 2003	18	18	6
Dec 2003	13	20	9
Jan 2004	16	17	4
Feb 2004	10	21	6
Mar 2004	15	23	12
Apr 2004	18	17	10
May 2004	46	47	14
Jun 2004	58	66	15
Jul 2004	59	64	15
Aug 2004	41	68	23
Sep 2004	32	58	14
Oct 2004	18	54	37
Nov 2004	18	52	31
Dec 2004	22	58	19
Jan 2005	25	56	18
Feb 2005	19	45	17
Mar 2005	15	41	26
Apr 2005	5	22	13
May 2005	7	31	37
Jun 2005	11	31	17
Jul 2005	12	30	15
Aug 2005	8	36	25
Sep 2005	7	51	29
Oct 2005	22	26	7
Nov 2005	12	34	13
Dec 2005	20	22	19
Jan 2006	9	38	20
Feb 2006	11	34	15
Mar 2006	22	26	17
Apr 2006	3	21	13
May 2006	18	36	25
Jun 2006	9	12	8
Jul 2006	5	18	7
Aug 2006	14	25	16
Sep 2006	6	20	13
Oct 2006	12	22	15
Nov 2006	7	19	16
Dec 2006	6	18	13
Jan 2007	5	18	16
Feb 2007	10	15	18
Mar 2007	12	17	16
Apr 2007	18	5	4
May 2007	11	11	11
Jun 2007	10	2	5
Jul 2007	13	14	8
Aug 2007	11	8	12
Sep 2007	16	9	6
Oct 2007	13	6	7
Nov 2007	10	3	3
Dec 2007	8	2	4
Jan 2008	8	5	5
Feb 2008	19	8	10
Mar 2008	15	10	3
Apr 2008	12	14	12
May 2008	9	9	9
Jun 2008	14	6	7
Jul 2008	12	5	7
Aug 2008	26	2	9
Sep 2008	28	8	5
Oct 2008	23	9	8
Nov 2008	5	4	1
Dec 2008	6	5	5
Jan 2009	9	1	2
Feb 2009	14	2	6
Mar 2009	17	9	5
Apr 2009	11	5	7
May 2009	13	11	3
Jun 2009	12	8	8
Jul 2009	10	10	7
Aug 2009	13	6	4
Sep 2009	7	2	6
Oct 2009	20	3	1
Nov 2009	14	5	1
Dec 2009	9	2	4
Jan 2010	9	2	5
Feb 2010	3	11	6
Mar 2010	21	7	3
Apr 2010	3	9	6
May 2010	12	9	8
Jun 2010	15	6	7
Jul 2010	3	4	5
Aug 2010	14	15	4
Sep 2010	9	6	7
Oct 2010	10	8	3
Nov 2010	21	9	4
Dec 2010	15	23	2
Jan 2011	10	5	1
Feb 2011	23	4	0
Mar 2011	11	10	5
Apr 2011	22	11	3
May 2011	9	6	4
Jun 2011	15	4	3
Jul 2011	18	3	3
Aug 2011	13	18	4
Sep 2011	27	3	2
Oct 2011	15	5	3
Nov 2011	13	12	5
Dec 2011	12	12	5
Jan 2012	12	32	4
Feb 2012	13	25	6
Mar 2012	7	29	7
Apr 2012	9	31	11
May 2012	10	18	4
Jun 2012	26	14	8
Jul 2012	11	14	9
Aug 2012	16	28	7
Sep 2012	7	14	6
Oct 2012	24	25	11
Nov 2012	24	27	11
Dec 2012	18	10	6
Jan 2013	13	5	10
Feb 2013	23	22	4
Mar 2013	16	22	10
Apr 2013	22	20	13
May 2013	18	16	10
Jun 2013	13	8	6
Jul 2013	15	7	4
Aug 2013	13	13	5
Sep 2013	10	7	2
Oct 2013	29	11	4
Nov 2013	11	7	5
Dec 2013	9	3	12
Jan 2014	14	4	3
Feb 2014	7	9	7
Mar 2014	16	7	4
Apr 2014	24	12	8
May 2014	11	20	6
Jun 2014	15	8	4
Jul 2014	27	12	7
Aug 2014	9	9	3
Sep 2014	21	37	8
Oct 2014	10	53	7
Nov 2014	6	25	2
Dec 2014	20	51	3
Jan 2015	5	45	3
Feb 2015	6	14	6
Mar 2015	17	38	7
Apr 2015	25	32	9
May 2015	9	18	4
Jun 2015	10	30	11
Jul 2015	15	19	8
Aug 2015	11	17	5
Sep 2015	15	20	5
Oct 2015	10	5	2
Nov 2015	16	10	7
Dec 2015	16	15	9
Jan 2016	28	12	6
Feb 2016	24	3	4
Mar 2016	28	8	6
Apr 2016	20	9	14
May 2016	14	13	13
Jun 2016	17	9	8
Jul 2016	14	17	11
Aug 2016	15	16	7
Sep 2016	12	4	5
Oct 2016	19	8	6
Nov 2016	17	5	6
Dec 2016	16	12	15
Jan 2017	23	11	9
Feb 2017	11	6	5
Mar 2017	0	8	3
Apr 2017	0	28	3
May 2017	1	18	1
Jun 2017	2	36	11
Jul 2017	27	27	10
Aug 2017	27	27	5
Sep 2017	20	21	2
Oct 2017	27	27	4
Nov 2017	75	76	7
Dec 2017	239	235	7
Jan 2018	92	92	2
Feb 2018	137	133	3
Mar 2018	34	33	7
Apr 2018	80	80	2
May 2018	100	100	2
Jun 2018	49	49	7
Jul 2018	20	20	2
Aug 2018	63	63	2
Sep 2018	50	50	2
Oct 2018	54	54	2
Nov 2018	73	73	2
Dec 2018	71	71	4
Jan 2019	64	62	2
Feb 2019	47	40	14
Mar 2019	26	26	18
Apr 2019	19	19	15
May 2019	18	17	4
Jun 2019	19	16	14
Jul 2019	25	24	17
Aug 2019	24	21	8
Sep 2019	25	24	3
Oct 2019	27	25	9
Nov 2019	21	18	8
Dec 2019	37	31	5
Jan 2020	27	23	5
Feb 2020	28	25	11
Mar 2020	15	13	7
Apr 2020	20	13	6
May 2020	11	8	3
Jun 2020	19	17	5
Jul 2020	23	22	4
Aug 2020	17	17	8
Sep 2020	37	32	7
Oct 2020	17	15	8
Nov 2020	38	27	18
Dec 2020	22	22	6
Jan 2021	24	24	9
Feb 2021	12	11	9
Mar 2021	16	14	9
Apr 2021	13	12	5
May 2021	13	10	4
Jun 2021	17	16	5
Jul 2021	25	21	10
Aug 2021	13	11	7
Sep 2021	28	25	16
Oct 2021	19	15	24
Nov 2021	14	13	23
Dec 2021	10	10	6
Jan 2022	31	28	11
Feb 2022	20	18	12
Mar 2022	23	23	10
Apr 2022	20	20	10
May 2022	40	38	26
Jun 2022	27	27	14
Jul 2022	23	18	3
Aug 2022	42	42	8
Sep 2022	40	39	16
Oct 2022	32	29	13
Nov 2022	39	25	15
Dec 2022	25	20	6
Jan 2023	49	39	10
Feb 2023	40	38	2
Mar 2023	48	45	10
Apr 2023	17	11	14
May 2023	17	14	16
Jun 2023	16	13	6
Jul 2023	49	30	10
Aug 2023	15	17	8
Sep 2023	24	21	7
Oct 2023	46	41	13
Nov 2023	28	26	7
Dec 2023	101	12	1
Jan 2024	180	2	0
Feb 2024	71	5	0
Mar 2024	85	8	1
Total	5858	6365	2445

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