Table 3
Distribution of apoptosis in colorectal cancer according to the level of DNA microsatellite instability (microsatellite instability-high (MSI-H), microsatellite instability-low (MSI-L), and microsatellite stable (MSS))
| Variables | Total3-151 | MSI-H (n=32) | MSI-L (n=30) | MSS (n=40) | p Value |
| Apoptosis | |||||
| Random % (mean (SD)) | 3.55 (1.99) | 2.52 (1.92) | 1.53 (1.47) | <0.00013-152 | |
| Median | 3.20 | 1.95 | 1.15 | ||
| Surface—apoptosis3-150 | |||||
| 0 (⩽ 1%) | 18 | 1 (3.45%) | 3 (11.11%) | 14 (41.18%) | <0.00013-152 |
| + (1–5 %) | 35 | 7 (24.14%) | 13 (48.15%) | 15 (44.12%) | |
| ++ (5–10 %) | 17 | 9 (31.03%) | 5 (18.52%) | 3 (8.82%) | |
| +++ (10–15 %) | 11 | 9 (31.03%) | 1 (3.70%) | 1 (2.94%) | |
| ++++ (>15%) | 9 | 3 (10.34%) | 5 (18.52%) | 1 (2.94%) | |
| Growing edge—apoptosis | |||||
| 0 (⩽ 1 %) | 41 | 7 (21.21%) | 10 (33.33%) | 24 (61.54%) | 0.0023-152 |
| + (1–5 %) | 47 | 17 (51.52%) | 16 (53.33%) | 14 (35.90%) | |
| ++ (5–10 %) | 14 | 9 (27.27%) | 4 (13.33%) | 1 (2.56%) | |
| Lumen—apoptosis3-160 | |||||
| 0 (little or none) | 53 | 12 (41.38%) | 13 (46.43%) | 28 (71.79%) | 0.0593-152 |
| + (some) | 34 | 12 (41.38%) | 13 (46.43%) | 9 (23.08%) | |
| ++ (widespread) | 9 | 5 (17.24%) | 2 (7.14%) | 2 (5.13%) | |
