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Sporadic HEV hepatitis in Italy
  1. A GRIECO,
  2. L MIELE,
  3. G GASBARRINI
  1. R GRILLO
  1. Institute of Internal Medicine
  2. Policlinico Universitario A Gemelli
  3. Catholic University of Sacred Heart, Rome, Italy
  4. Institute of Microbiology
  5. Policlinico Universitario A Gemelli
  6. Catholic University of Sacred Heart, Rome, Italy
  1. Dr G Antonio, Institute of Internal Medicine, Catholic University of Sacred Heart, Largo Gemelli 8-00168 Rome, Italy.antgrieco{at}katamail.com

https://doi.org/10.1136/gut.48.4.580

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    Editor,—We read with great interest the paper of McCrudden et al concerning acute hepatitis E (HEV) in the UK ((2000) Gut 46:732–3; OpenUrlPubMedWeb of Science). We agree wholeheartedly with the authors that this form of hepatitis is on the increase in industrialised countries. In Italy, the reported prevalence of anti-HEV IgG positivity ranges from 0.74% to 1.94%,1 although a recent study found a prevalence of 2.6% in one small town in central Italy.2 A value of 1.5% has been reported for the general adult population of the Republic of San Marino.3

    We have recently observed two cases of acute hepatitis E with no evidence of any known risk factors.

    Case 1. In September 1997, a 45 …

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