You are here

Article Text

Article menu
Download PDFPDF
Motility and visceral sensation
Effects of octreotide on responses to colorectal distension in the rat
  1. X Su,
  2. M B Burton†,
  3. G F Gebhart
  1. Department of Pharmacology, Bowen Science Building, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
  1. Dr G F Gebhart, Department of Pharmacology, Bowen Science Building, University of Iowa, Iowa City, IA 52242-1109, USA.gf-gebhart{at}uiowa.edu

Abstract

BACKGROUND AND AIMS It has been suggested that the analgesic effect of the somatostatin analogue octreotide in visceral pain involves peripheral mechanisms. We evaluated the effect of octreotide on responses to noxious colorectal distension in rats.

METHODS In a behavioural study, pressor and electromyographic responses to colorectal distension were evaluated before and after intravenous or intrathecal administration of octreotide. In pelvic nerve afferent fibre recordings, responses of mechanosensitive fibres innervating the colon to noxious colorectal distension (80 mm Hg, 30 seconds) were tested before and after octreotide.

RESULTS Octreotide was ineffective in attenuating responses to colorectal distension in either normal or acetic acid inflamed colon when administered intravenously but attenuated responses when given intrathecally. Administration of octreotide over a broad dose range (0.5 μg/kg to 2.4 mg/kg) did not alter responses of afferent fibres to noxious colorectal distension in untreated, or acetic acid or zymosan treated colons.

CONCLUSIONS In the rat, octreotide has no peripheral (pelvic nerve) modulatory action in visceral nociception. The antinociceptive effect of octreotide in this model of visceral nociception is mediated by an action at central sites.

  • octreotide
  • colorectal distension
  • electromyographic responses
  • afferent fibres
  • visceral pain
  • analgesic effect
  • rat

  • Abbreviations used in this paper

    IBS
    irritable bowel syndrome
    CRD
    colorectal distension
    EMG
    electromyogram
    MAP
    mean arterial pressure
    VMR
    visceromotor response
    HAc
    acetic acid
    SRFs
    stimulus-response functions
    SSTR
    somatostatin receptor

    • https://doi.org/10.1136/gut.48.5.676

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    • Abbreviations used in this paper

      IBS
      irritable bowel syndrome
      CRD
      colorectal distension
      EMG
      electromyogram
      MAP
      mean arterial pressure
      VMR
      visceromotor response
      HAc
      acetic acid
      SRFs
      stimulus-response functions
      SSTR
      somatostatin receptor
      • View Full Text

      Linked Articles