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Gut 48:696-701 doi:10.1136/gut.48.5.696
  • Coeliac disease

Candidate gene regions and genetic heterogeneity in gluten sensitivity

Table 3

Linkage heterogeneity test between subgroups. The highest maximum likelihood scores (MLS) in the total sample (ALL) are compared with the scores in the subgroups (FM, FF, CD, DH), and respective M statistics with significance obtained by simulation are presented

Marker Group MLS M test χ2 Simulated p value
D5S2111 FM 2.06 5.44 0.019
FF 0.00
ALL 0.88
D11S4142 FM 2.10 3.43 0.088
FF 0.01
ALL 1.37
D2S116 FM 2.54 1.96 0.360
FF 0.25
ALL 2.36
D5S2111 CD 0.06 3.76 0.057
DH 1.64
ALL 0.88
D11S4142 CD 0.32 1.61 0.265
DH 1.40
ALL 1.37
D2S116 CD 2.71 2.55 0.245
DH 0.21
ALL 2.36

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