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Gut 49:650-655 doi:10.1136/gut.49.5.650
  • Inflammation and inflammatory bowel disease

Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs

Table 2

Urinary excretion of probes induced by celecoxib. Results illustrate urinary excretion of sucrose, lactulose/mannitol (lac/man), and sucralose in nine subjects at baseline, and after two days of 200 mg/day celecoxib and 750 mg/day naproxen

Probe Baseline Celecoxib Naproxen
Sucrose (mg) 84.7 (12.6) 55.7 (5.4) 126.4 (21.3)
Lac/man (ratio) 0.023 (0.003) 0.023 (0.005) 0.027 (0.002)2-150
Sucralose (mg) 31.1 (3.4) 29.1 (4.2) 29.7 (5.6)
  • Values are mean (SEM).

  • 2-150 p<0.05 versus baseline values.

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