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Gut 50:118-122 doi:10.1136/gut.50.1.118
  • Liver and biliary disease

Biliary drainage for obstructive jaundice enhances hepatic energy status in humans: a 31-phosphorus magnetic resonance spectroscopy study

Table 2

Hepatic metabolism measured by 31-phosphorus magnetic resonance spectroscopy ( 31P MRS)

Jaundice group (n=10)
31P MRS measurement Healthy controls (n=10) At presentation After drainage
Data are median (interquartile range).
††p<0.01 healthy controls versus jaundice group at presentation.
**p<0.01 jaundice group after drainage versus value at presentation.
ATP, adenosine triphosphate; Pi, inorganic phosphate; PME, phosphomonoester; PDE, phosphodiester; TP, total visible phosphate; pHic, intracellular pH.
ATP/Pi 1.25 (1.01–1.6) 1.4 (1.17–1.69) 1.97 (1.4–2.48)**
PME/PDE 0.38 (0.36–0.5)†† 0.71 (0.54–0.82) 0.93 (0.65–1.1)**
PME/TP % 10.3 (8.7–11.5)†† 15.4 (13.1–17.7) 17.6 (14.2–18.9)
PDE/TP % 25 (22.1–26.7) 25.2 (20.5–27.4) 19.8 (16.6–24.5)**
pHic 7.32 (7.16–7.38) 7.44 (7.29–7.47) 7.37 (7.27–7.45)

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