You are here

Article Text

Article menu
Download PDFPDF
Review
Gene therapy for liver diseases: recent strategies for treatment of viral hepatitis and liver malignancies
  1. V Schmitz1,
  2. C Qian2,
  3. J Ruiz2,
  4. B Sangro2,
  5. I Melero2,
  6. G Mazzolini2,
  7. I Narvaiza2,
  8. J Prieto2
  1. 1Gene Therapy Unit, Department of Internal Medicine, Clinica Universitaria, Faculty of Medicine, Universidad de Navarra, Pamplona Spain and University Hospital Bonn, Internal Medicine, Germany
  2. 2Gene Therapy Unit, Department of Internal Medicine, Clinica Universitaria, Faculty of Medicine, Universidad de Navarra, Pamplona Spain
  1. Correspondence to:
    Dr Volker Schmitz, Universitätsklinikum Bonn, Medizinische Klinik I, Rhein. Friedrich-Wilhelms-Universität, Sigmund-Freud-Str.25, D-53105 Bonn, Germany;
    Volker.Schmitz{at}uni-bonn.de

Abstract

Gene therapy has emerged as a powerful and very plastic tool to regulate biological functions in diseased tissues with application in virtually all medical fields. An increasing number of experimental and clinical studies underline the importance of genes as curative agents in the future. However, intense research is needed to evaluate the potential of gene therapy to improve efficacy and minimise the toxicity of the procedure.

  • gene therapy
  • liver disease
  • viral hepatitis
  • liver malignancies
  • ITR, inverted terminal repeat
  • AAV, adeno associated virus
  • HSV, herpes simplex virus
  • IFN-α, interferon α
  • IL, interleukin
  • AFP, α fetoprotein
  • GM-CSF, granulocyte macrophage-colony stimulating factor
  • AdCE1, adenovirus containing the core and E1 sequences from hepatitis C virus
  • AdIL-12, adenovirus containing genes of IL-12
  • WHV, woodchuck hepatitis virus
  • HCC, hepatocellular carcinoma
  • HSV-tk, HSV-thymidine kinase

https://doi.org/10.1136/gut.50.1.130

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes