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Expression of isoforms of nitric oxide synthase in collagenous colitis
  1. E A B Cameron1,
  2. S J Middleton1,
  3. P J Roberts2
  1. 1Department of Gastroenterology, Addenbrooke's NHS Trust, Cambridge CB2 2QQ, UK
  2. 2Department of Gastroenterology, Hinchingbrooke NHS Trust, Huntingdon, Cambridge PE18 8NT, UK
  1. Correspondence to:
    S J Middleton;
    stephen.middleton{at}addenbrookes.nhs.uk

https://doi.org/10.1136/gut.50.6.899

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    We read with interest the study by Perner et al (Gut 2001;49:387–94) investigating expression of various isoforms of nitric oxide synthase (iNOS, eNOS, and nNOS) in non-inflamed colon, collagenous colitis, and ulcerative colitis. Inducible NOS (iNOS) was identified by immunohistochemical analysis in the epithelium of patients with non-inflamed colon. The authors concluded that this might be a result of bowel preparation with bisacodyl.

    Increased synthesis of nitric oxide has been detected by a number of different methods in patients with ulcerative colitis.1,2 We have previously found physiological expression of iNOS in histologically normal colon using reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, and immunoblotting.3 Tissue from three different sources was studied. Surgical specimens were obtained from patients undergoing colectomy for colorectal cancer who had undergone …

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