Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease

B R Yacyshyn; W Y Chey; J Goff; B Salzberg; R Baerg; A L Buchman; J Tami; R Yu; E Gibiansky; W R Shanahan

doi:10.1136/gut.51.1.30

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Inflammatory bowel disease

Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease

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	Abstract	Full	Pdf
Jun 2002	87	97	123
Jul 2002	66	122	82
Aug 2002	16	34	18
Sep 2002	20	51	21
Oct 2002	15	40	14
Nov 2002	19	54	23
Dec 2002	19	31	13
Jan 2003	17	30	9
Feb 2003	4	16	15
Mar 2003	7	32	13
Apr 2003	5	18	15
May 2003	4	19	14
Jun 2003	3	16	10
Jul 2003	15	49	11
Aug 2003	18	11	3
Sep 2003	11	23	9
Oct 2003	34	30	7
Nov 2003	29	19	9
Dec 2003	24	21	9
Jan 2004	28	13	7
Feb 2004	17	11	8
Mar 2004	23	23	4
Apr 2004	28	34	19
May 2004	42	45	18
Jun 2004	56	48	11
Jul 2004	54	64	17
Aug 2004	59	67	11
Sep 2004	31	53	8
Oct 2004	21	47	18
Nov 2004	22	42	6
Dec 2004	22	55	20
Jan 2005	14	48	23
Feb 2005	16	44	16
Mar 2005	11	33	13
Apr 2005	9	21	17
May 2005	12	38	18
Jun 2005	16	22	7
Jul 2005	7	19	4
Aug 2005	12	30	29
Sep 2005	11	18	11
Oct 2005	10	37	15
Nov 2005	9	36	24
Dec 2005	11	59	9
Jan 2006	11	32	8
Feb 2006	8	22	13
Mar 2006	4	26	10
Apr 2006	5	18	4
May 2006	9	19	12
Jun 2006	13	20	16
Jul 2006	13	11	4
Aug 2006	8	22	10
Sep 2006	7	21	6
Oct 2006	12	19	9
Nov 2006	9	25	11
Dec 2006	11	22	7
Jan 2007	9	11	6
Feb 2007	5	13	8
Mar 2007	7	14	10
Apr 2007	23	8	8
May 2007	25	7	14
Jun 2007	15	3	4
Jul 2007	10	3	2
Aug 2007	20	1	3
Sep 2007	10	6	3
Oct 2007	12	3	3
Nov 2007	17	2	1
Dec 2007	9	2	2
Jan 2008	7	3	3
Feb 2008	16	4	12
Mar 2008	25	4	3
Apr 2008	24	2	2
May 2008	10	3	0
Jun 2008	8	1	1
Jul 2008	12	2	2
Aug 2008	16	2	4
Sep 2008	29	0	0
Oct 2008	17	2	2
Nov 2008	17	9	5
Dec 2008	9	1	4
Jan 2009	12	4	5
Feb 2009	7	3	4
Mar 2009	30	3	4
Apr 2009	11	1	1
May 2009	12	4	4
Jun 2009	22	1	1
Jul 2009	17	1	0
Aug 2009	17	3	0
Sep 2009	14	2	3
Oct 2009	11	1	1
Nov 2009	24	4	6
Dec 2009	10	0	0
Jan 2010	16	2	2
Feb 2010	11	3	4
Mar 2010	32	2	4
Apr 2010	13	4	2
May 2010	4	1	3
Jun 2010	9	4	6
Jul 2010	4	3	5
Aug 2010	10	2	2
Sep 2010	8	3	4
Oct 2010	8	7	2
Nov 2010	21	1	0
Dec 2010	4	7	4
Jan 2011	9	2	3
Feb 2011	9	5	2
Mar 2011	17	4	3
Apr 2011	16	9	1
May 2011	18	5	3
Jun 2011	11	1	2
Jul 2011	11	0	0
Aug 2011	11	0	0
Sep 2011	20	1	2
Oct 2011	13	3	2
Nov 2011	13	3	4
Dec 2011	17	15	6
Jan 2012	19	13	8
Feb 2012	9	9	7
Mar 2012	8	2	6
Apr 2012	16	7	4
May 2012	16	18	5
Jun 2012	8	5	9
Jul 2012	13	19	6
Aug 2012	21	10	14
Sep 2012	10	8	9
Oct 2012	20	10	9
Nov 2012	18	11	7
Dec 2012	26	9	7
Jan 2013	27	12	7
Feb 2013	25	11	5
Mar 2013	20	19	2
Apr 2013	20	12	5
May 2013	23	6	9
Jun 2013	14	8	1
Jul 2013	9	10	4
Aug 2013	25	4	4
Sep 2013	12	15	5
Oct 2013	10	20	2
Nov 2013	14	11	7
Dec 2013	14	9	16
Jan 2014	14	7	1
Feb 2014	12	9	5
Mar 2014	14	17	7
Apr 2014	11	19	9
May 2014	25	21	6
Jun 2014	8	34	5
Jul 2014	24	46	6
Aug 2014	16	37	3
Sep 2014	9	12	2
Oct 2014	4	5	3
Nov 2014	10	11	5
Dec 2014	7	5	5
Jan 2015	6	2	2
Feb 2015	7	13	11
Mar 2015	26	13	5
Apr 2015	10	6	6
May 2015	9	10	3
Jun 2015	1	4	3
Jul 2015	11	3	3
Aug 2015	5	2	4
Sep 2015	16	13	3
Oct 2015	8	8	5
Nov 2015	12	2	3
Dec 2015	17	5	6
Jan 2016	8	5	4
Feb 2016	11	4	5
Mar 2016	6	6	7
Apr 2016	8	4	7
May 2016	26	15	4
Jun 2016	6	4	3
Jul 2016	11	12	4
Aug 2016	7	8	4
Sep 2016	12	8	2
Oct 2016	15	65	9
Nov 2016	11	63	2
Dec 2016	9	27	5
Jan 2017	15	31	8
Feb 2017	7	48	6
Mar 2017	0	47	6
Apr 2017	0	44	2
May 2017	1	37	4
Jun 2017	4	27	4
Jul 2017	20	20	4
Aug 2017	26	26	3
Sep 2017	19	19	1
Oct 2017	23	23	3
Nov 2017	21	21	3
Dec 2017	21	21	5
Jan 2018	14	14	0
Feb 2018	28	28	5
Mar 2018	29	29	2
Apr 2018	31	31	2
May 2018	17	18	0
Jun 2018	21	21	1
Jul 2018	19	19	0
Aug 2018	20	20	3
Sep 2018	19	19	2
Oct 2018	12	12	2
Nov 2018	11	11	1
Dec 2018	20	20	6
Jan 2019	13	13	1
Feb 2019	19	19	5
Mar 2019	25	25	6
Apr 2019	8	8	9
May 2019	12	12	6
Jun 2019	10	10	5
Jul 2019	18	18	11
Aug 2019	9	9	2
Sep 2019	8	7	11
Oct 2019	12	12	7
Nov 2019	8	7	6
Dec 2019	10	7	4
Jan 2020	13	12	4
Feb 2020	6	6	5
Mar 2020	22	21	10
Apr 2020	6	5	3
May 2020	4	3	4
Jun 2020	11	11	6
Jul 2020	13	12	4
Aug 2020	3	3	6
Sep 2020	22	22	4
Oct 2020	12	12	4
Nov 2020	17	13	6
Dec 2020	24	23	7
Jan 2021	21	17	5
Feb 2021	18	18	8
Mar 2021	30	28	5
Apr 2021	11	8	3
May 2021	9	6	7
Jun 2021	13	10	3
Jul 2021	9	9	9
Aug 2021	12	10	7
Sep 2021	15	13	9
Oct 2021	7	7	19
Nov 2021	13	10	22
Dec 2021	11	10	5
Jan 2022	27	29	9
Feb 2022	30	26	8
Mar 2022	29	31	11
Apr 2022	26	24	6
May 2022	24	23	21
Jun 2022	30	26	5
Jul 2022	19	18	4
Aug 2022	27	26	7
Sep 2022	33	31	10
Oct 2022	40	39	12
Nov 2022	26	25	6
Dec 2022	39	39	6
Jan 2023	27	25	11
Feb 2023	41	39	4
Mar 2023	30	25	7
Apr 2023	10	9	6
May 2023	4	4	6
Jun 2023	36	35	7
Jul 2023	7	6	7
Aug 2023	6	5	8
Sep 2023	47	46	6
Oct 2023	124	122	11
Nov 2023	213	212	4
Dec 2023	104	12	5
Jan 2024	32	1	1
Feb 2024	61	6	3
Mar 2024	40	1	0
Total	4721	4807	1885

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