You are here

Article Text

Article menu
Download PDFPDF
Review
Molecular pathogenesis of iron overload
  1. D Trinder1,
  2. C Fox2,
  3. G Vautier3,
  4. J K Olynyk4
  1. 1Department of Medicine and Western Australian Institute for Medical Research, University of Western Australia, Australia
  2. 2Department of Gastroenterology, Fremantle Hospital, Fremantle, Western Australia, Australia
  3. 3Department of Gastroenterology, Fremantle Hospital, Fremantle, Western Australia, Australia, and Royal Defence Medical College, Gosport, UK
  4. 4Department of Medicine and Western Australian Institute for Medical Research, University of Western Australia, Australia, and Department of Gastroenterology, Fremantle Hospital, Fremantle, Western Australia, Australia
  1. Correspondence to:
    Associate Professor J Olynyk, University Department of Medicine, PO Box 480, Fremantle 6959, Western Australia, Australia;
    jolynyk{at}cyllene.uwa.edu.au

Abstract

Our current understanding of iron absorption under normal conditions is presented, together with an overview of the clinical disorders of iron overload and the molecular processes that contribute to increased iron deposition in iron overload. Recently, a number of new genes involved in iron metabolism have been identified which is allowing the molecular mechanisms of iron absorption to be elucidated.

  • divalent metal transporter 1
  • ferroportin
  • iron regulating elements
  • haemochromatosis
  • haephestin
  • hepcidin
  • iron
  • DMT1, divalent metal transporter 1
  • HFE, haemochromatosis protein
  • HH, hereditary haemochromatosis
  • IRE, iron regulatory element
  • IRP, iron regulatory protein
  • NTBI, non-transferrin bound iron
  • TBI, transferrin bound iron
  • TfR1, transferrin receptor 1
  • TfR2, transferrin receptor 2

https://doi.org/10.1136/gut.51.2.290

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text