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Issue information

[Front cover][Table of contents PDF]

Leading article

  • Hepatocellular carcinoma: is current therapy really altering outcome?

    • P J Johnson
    Gut 2002;51:4 459-462 doi:10.1136/gut.51.4.459

  • Digest

    • Ian Forgacs
    Gut 2002;51:4 459 doi:10.1136/gut.51.4.459-a

Commentaries

  • FAP: another indication to treat H pylori

    • B Leggett
    Gut 2002;51:4 463-464 doi:10.1136/gut.51.4.463

  • Functional dyspepsia: bye-bye to PPIs

    • O Nyrén
    Gut 2002;51:4 464-465 doi:10.1136/gut.51.4.464

Clinical @lert

  • Do those with positive faecal occult blood tests need upper gastrointestinal investigations if no colorectal cancer cause is found?

    • M H Robinson
    Gut 2002;51:4 466-467 doi:10.1136/gut.51.4.466

Debate

  • Laparoscopic fundoplication is the treatment of choice for gastro-oesophageal reflux disease

    • L Lundell
    Gut 2002;51:4 468-471 doi:10.1136/gut.51.4.468

  • Laparoscopic fundoplication is the treatment of choice for gastro-oesophageal reflux disease

    • J P Galmiche,
    • F Zerbib
    Gut 2002;51:4 472-474 doi:10.1136/gut.51.4.472

Gastro-oesophageal reflux

  • Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux disease

    • T I Omari,
    • C P Barnett,
    • M A Benninga,
    • R Lontis,
    • L Goodchild,
    • R R Haslam,
    • J Dent,
    • G P Davidson
    Gut 2002;51:4 475-479 doi:10.1136/gut.51.4.475

Helicobacter pylori

  • Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions

    • J Yu,
    • W K Leung,
    • M Y Y Go,
    • M C W Chan,
    • K F To,
    • E K W Ng,
    • F K L Chan,
    • T K W Ling,
    • S C S Chung,
    • J J Y Sung
    Gut 2002;51:4 480-484 doi:10.1136/gut.51.4.480

  • Impact of Helicobacter pylori infection and mucosal atrophy on gastric lesions in patients with familial adenomatous polyposis

    • S Nakamura,
    • T Matsumoto,
    • Y Kobori,
    • M Iida
    Gut 2002;51:4 485-489 doi:10.1136/gut.51.4.485

  • Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats

    • P V Sherwood,
    • J I D Wibawa,
    • J C Atherton,
    • N Jordan,
    • D Jenkins,
    • D A Barrett,
    • P N Shaw,
    • R C Spiller
    Gut 2002;51:4 490-495 doi:10.1136/gut.51.4.490

Motility and visceral sensation

  • Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation

    • G L Lyford,
    • C-L He,
    • E Soffer,
    • T L Hull,
    • S A Strong,
    • A J Senagore,
    • L J Burgart,
    • T Young-Fadok,
    • J H Szurszewski,
    • G Farrugia
    Gut 2002;51:4 496-501 doi:10.1136/gut.51.4.496

  • Double blind, randomised, placebo controlled study of four weeks of lansoprazole for the treatment of functional dyspepsia in Chinese patients

    • W M Wong,
    • B C Y Wong,
    • W K Hung,
    • Y K Yee,
    • A W C Yip,
    • M L Szeto,
    • F M Y Fung,
    • T S M Tong,
    • K C Lai,
    • W H C Hu,
    • M F Yuen,
    • S K Lam
    Gut 2002;51:4 502-506 doi:10.1136/gut.51.4.502

Small intestine

  • Effect of stress on the paracellular barrier in the rat ileum

    • E Mazzon,
    • G C Sturniolo,
    • D Puzzolo,
    • N Frisina,
    • W Fries
    Gut 2002;51:4 507-513 doi:10.1136/gut.51.4.507

  • Autophagocytosis of the apical membrane in microvillus inclusion disease

    • K Reinshagen,
    • H Y Naim,
    • K-P Zimmer
    Gut 2002;51:4 514-521 doi:10.1136/gut.51.4.514

  • Antidiarrhoeal properties of a novel sigma ligand (JO 2871) on toxigenic diarrhoea in mice: mechanisms of action

    • V Theodorou,
    • M Chovet,
    • H Eutamene,
    • H Fargeau,
    • M Dassaud,
    • M Toulouse,
    • C Bihoreau,
    • F J Roman,
    • L Bueno
    Gut 2002;51:4 522-528 doi:10.1136/gut.51.4.522

Inflammation and inflammatory bowel disease

  • ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease

    • E Rijcken,
    • C F Krieglstein,
    • C Anthoni,
    • M G Laukoetter,
    • R Mennigen,
    • H U Spiegel,
    • N Senninger,
    • C F Bennett,
    • G Schuermann
    Gut 2002;51:4 529-535 doi:10.1136/gut.51.4.529

  • Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines

    • R A J Ransford,
    • M J S Langman
    Gut 2002;51:4 536-539 doi:10.1136/gut.51.4.536

  • Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation

    • M T Salmela,
    • T T MacDonald,
    • D Black,
    • B Irvine,
    • T Zhuma,
    • U Saarialho-Kere,
    • S L F Pender
    Gut 2002;51:4 540-547 doi:10.1136/gut.51.4.540

Therapy update

  • Which 5-ASA?

    • S P L Travis
    Gut 2002;51:4 548-549 doi:10.1136/gut.51.4.548

Cancer

  • Flat and depressed colorectal tumours in a southern Swedish population: a prospective chromoendoscopic and histopathological study

    • S Tsuda,
    • B Veress,
    • E Tóth,
    • F-T Fork
    Gut 2002;51:4 550-555 doi:10.1136/gut.51.4.550

  • Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-XL and Mcl-1 expressing human cholangiocarcinoma cells

    • A C Okaro,
    • D A Fennell,
    • M Corbo,
    • B R Davidson,
    • F E Cotter
    Gut 2002;51:4 556-561 doi:10.1136/gut.51.4.556

  • Natural history of primary sclerosing cholangitis and prognostic value of cholangiography in a Dutch population

    • C Y Ponsioen,
    • S M E Vrouenraets,
    • W Prawirodirdjo,
    • R Rajaram,
    • E A J Rauws,
    • C J J Mulder,
    • J B Reitsma,
    • S H Heisterkamp,
    • G N J Tytgat
    Gut 2002;51:4 562-566 doi:10.1136/gut.51.4.562

  • Cigarette smoking, appendectomy, and tonsillectomy as risk factors for the development of primary sclerosing cholangitis: a case control study

    • S A Mitchell,
    • M Thyssen,
    • T R Orchard,
    • D P Jewell,
    • K A Fleming,
    • R W Chapman
    Gut 2002;51:4 567-573 doi:10.1136/gut.51.4.567

Pancreatic disease

  • Pancreatic stellate cells contribute to regeneration early after acute necrotising pancreatitis in humans

    • A Zimmermann,
    • B Gloor,
    • A Kappeler,
    • W Uhl,
    • H Friess,
    • M W Büchler
    Gut 2002;51:4 574-578 doi:10.1136/gut.51.4.574

  • Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells

    • R Jaster,
    • G Sparmann,
    • J Emmrich,
    • S Liebe
    Gut 2002;51:4 579-584 doi:10.1136/gut.51.4.579

Liver disease

  • Histological features and HLA class II alleles in hepatitis C virus chronically infected patients with persistently normal alanine aminotransferase levels

    • C Renou,
    • P Halfon,
    • S Pol,
    • P Cacoub,
    • E Jouve,
    • J P Bronowicki,
    • J P Arpurt,
    • H Rifflet,
    • M Picon,
    • X Causse,
    • V Canva,
    • J Denis,
    • A Tran,
    • M Bourliére,
    • D Ouzan,
    • A Pariente,
    • S Dantin,
    • L Alric,
    • V Cartier,
    • M Reville,
    • S Caillat-Zucman
    Gut 2002;51:4 585-590 doi:10.1136/gut.51.4.585

  • Regulation of circulating immune complexes by complement receptor type 1 on erythrocytes in chronic viral liver diseases

    • J Miyaike,
    • Y Iwasaki,
    • A Takahashi,
    • H Shimomura,
    • H Taniguchi,
    • N Koide,
    • K Matsuura,
    • T Ogura,
    • K Tobe,
    • T Tsuji
    Gut 2002;51:4 591-596 doi:10.1136/gut.51.4.591

Case report

  • Fatal hepatitis B reactivation following discontinuation of nucleoside analogues for chronic hepatitis B

    • S G Lim,
    • C T Wai,
    • A Rajnakova,
    • T Kajiji,
    • R Guan
    Gut 2002;51:4 597-599 doi:10.1136/gut.51.4.597

Gut file

  • Collagenous colitis with mucosal tears on endoscopic insufflation: a unique presentation

    • M Cruz-Correa,
    • F Milligan,
    • F M Giardiello,
    • T M Bayless,
    • M Torbenson,
    • J H Yardley,
    • Frank W Jackson,
    • F Wilson Jackson
    Gut 2002;51:4 600 doi:10.1136/gut.51.4.600

Review

  • Hepatitis C and HIV-1 coinfection

    • A H Mohsen,
    • P Easterbrook,
    • C B Taylor,
    • S Norris
    Gut 2002;51:4 601-608 doi:10.1136/gut.51.4.601

Letters

  • Susceptibility to primary sclerosing cholangitis in Brazil is associated with HLA-DRB1*13 but not with tumour necrosis factor α −308 promoter polymorphism

    • P L Bittencourt,
    • S A Palacios,
    • E L R Cançado,
    • F J Carrilho,
    • G Porta,
    • J Kalil,
    • A C Goldberg
    Gut 2002;51:4 609-610 doi:10.1136/gut.51.4.609

  • Slow transit constipation: more than one disease?

    • C Pehl,
    • T Schmidt,
    • W Schepp
    1. Commentator:
      • M A Kamm and
      • A V Emmanuel
    Gut 2002;51:4 610 doi:10.1136/gut.51.4.610

  • Surveillance for hepatocellular carcinoma in liver cirrhosis: have programmes improved because patients have?

    • E Giannini,
    • R Testa
    Gut 2002;51:4 611 doi:10.1136/gut.51.4.611

  • Rectal proliferation and alcohol abuse

    • K Filion
    1. Commentator:
      • H K Seitz and
      • C Conradt
    Gut 2002;51:4 611-612 doi:10.1136/gut.51.4.611-a

  • Motilin agonists and dyspepsia: throwing out the baby with the bath water

    • M Camilleri
    1. Commentator:
      • N J Talley and
      • M Verlinden
    Gut 2002;51:4 612-613 doi:10.1136/gut.51.4.612

  • Reducing dyspepsia costs in the community

    • A Duggan,
    • J Westbrook
    1. Commentator:
      • R Valori
    Gut 2002;51:4 613 doi:10.1136/gut.51.4.613

  • Causes of obvious jaundice in South West Wales

    • E H Forrest,
    • J A H Forrest
    1. Commentator:
      • J G C Kingham,
      • M W Whitehead,
      • and I Hainsworth
    Gut 2002;51:4 613-614 doi:10.1136/gut.51.4.613-a

  • Behaviour of Crohn's disease according to the Vienna classification

    • D B Sachar
    1. Commentator:
      • E Louis and
      • J Belaiche
    Gut 2002;51:4 614-615 doi:10.1136/gut.51.4.614

BOOK REVIEW

  • Pediatric Gastroenterology and Nutrition in Clinical Practice: Edited by C H Lifschitz. New York: Marcel Dekker, 2002, B/W, pp 869. ISBN 0 8247 0510 6

    • L T Weaver
    Gut 2002;51:4 615 doi:10.1136/gut.51.4.615

  • Gastrointestinal Polyps: Edited by N Haboubi, K Geboes, N Shepherd, et al. Greenwich: Medical Media, 2002, £65.00, colour, pp170. ISBN 1-90015-121-9

    • P Domizio
    Gut 2002;51:4 615 doi:10.1136/gut.51.4.615-a

  • Upper Gastrointestinal Surgery, 2nd Edn: Edited by S M Griffin, S A Raimes. Philadelphia: WB Saunders, 2001, B/W, pp 474. ISBN 0 7020 2587 9

    • M Winslet
    Gut 2002;51:4 615-616 doi:10.1136/gut.51.4.615-b

  • Challenges in Inflammatory Bowel Disease: Edited by D P Jewell, B F Warren, N J Mortensen. Oxford: Blackwell Science, 2001, £59.50, B/W, pp 294. ISBN 0 632 05169 8

    • D Sachar
    Gut 2002;51:4 616 doi:10.1136/gut.51.4.616

CORRECTION

  • CORRECTION

    Gut 2002;51:4 616 doi:10.1136/gut.51.4.616-a

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