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Influence of clinical factors, drug use, and food intake on the glutathione system
  1. H Shirin1,
  2. J T Pinto2,
  3. S F Moss3
  1. 1Tel Aviv University/Edith Wolfson Medical Center, Holon, Israel
  2. 2American Health Foundation, Valhalla, NY, USA
  3. 3Brown University/Rhode Island Hospital, Providence, RI, USA
  1. Correspondence to:
    S F Moss, Rhode Island Hospital, 593 Eddy St, APC 445, Providence, RI 02903, USA;
    Steven_Moss_MD{at}Brown.edu

https://doi.org/10.1136/gut.52.1.154

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    In a previous issue of Gut, Hoensch and colleagues (Gut 2002;50:235–40) using antral and duodenal biopsies, reported on a variety of factors such as sex, age, drug use, and food intake that influence the concentration of glutathione and the activity of glutathione S-transferase. All of these factors either singly or in combination significantly affect glutathione metabolism within the gastric mucosa.

    Curiously, one critical factor that may have influenced their measurements, namely Helicobacter pylori infection, was not mentioned in their paper. This omission is particularly important as the majority of the patients that these investigators examined had endoscopic findings strongly suggestive of infection with H pylori (gastric erythema, erosions, or ulcers). Previous studies by some of the coauthors in the Hoensch paper1,2 as well as by our group3 have clearly demonstrated that H pylori infection is associated with marked depletion by approximately 50% of reduced glutathione within the gastric epithelium, and that concentrations of reduced epithelial glutathione are restored to …

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