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Gut 52:57-62 doi:10.1136/gut.52.1.57
  • Small intestine

An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients

Table 3

Percentage of CD3+ lamina propria lymphocytes expressing CD25 after culture with medium alone, peptic-tryptic digest of gliadin, or native or deamidated peptide

DQ8+ patients DQ8− patients
*Data are mean (SD).
Medium 1.7 (0.8)* 1.8 (0.7)
Peptic-triptic digest of gliadin 9.1 (3.3) 9.3 (1.4)
Native peptide 6.3 (1.4) 2.4 (0.8)
Deamidated peptide 7.1 (1.6) 2.5 (0.9)

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