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Gut 2003;52:7 doi:10.1136/gut.52.1.7
  • Commentary

HLA-DQ8 as an Ir gene in coeliac disease

  1. K E A Lundin
  1. Department of Medicine and Institute of Immunology, Rikshospitalet, N-0027 Oslo, Norway; knut.lundin{at}rikshospitalet.no

    Abstract

    DQ8 restricted gliadin peptide is immunogenic in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in this disease

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