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Gut 52:1397-1402 doi:10.1136/gut.52.10.1397
  • Oesophagus

Effect of the GABAB agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors

Table 3

Symptom severity scores during treatment with omeprazole 20 mg twice daily and during omeprazole 20 mg twice daily plus baclofen 10 mg three times daily

Symptom Omeprazole Omeprazole+baclofen p Value
Values are mean (SEM).
Heartburn 1.6 (0.4) 0.8 (0.3) <0.05
Acid regurgitation 0.7 (0.2) 0.6 (0.3) NS
Food regurgitation 0.4 (0.2) 0.4 (0.2) NS
Chest pain 1.7 (0.3) 1.1 (0.3) NS
Dysphagia 0.5 (0.2) 0.4 (0.2) NS
Nausea 1.3 (0.3) 0.9 (0.2) NS
Choking 0.6 (0.3) 0.1 (0.1) <0.05
Odynophagia 0.8 (0.3) 0.1 (0.1) 0.01
Throat ache 1.1 (0.3) 0.6 (0.3) 0.07
Hoarseness 0.5 (0.3) 0.4 (0.2) NS
Coughing 0.4 (0.2) 0.1 (0.1) NS
Dyspnoea 0.3 (0.2) 0.1 (0.1) NS
Vomiting 0.5 (0.3) 0.4 (0.2) NS
Overall 10.3 (1.7) 5.8 (1.3) <0.01

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