Antibiotics with a selective aerobic or anaerobic spectrum have different therapeutic activities in various regions of the colon in interleukin 10 gene deficient mice

F Hoentjen; H J M Harmsen; H Braat; C D Torrice; B A Mann; R B Sartor; L A Dieleman

doi:10.1136/gut.52.12.1721

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Inflammatory bowel disease

Antibiotics with a selective aerobic or anaerobic spectrum have different therapeutic activities in various regions of the colon in interleukin 10 gene deficient mice

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	Abstract	Full	Pdf
Nov 2003	72	78	42
Dec 2003	45	122	67
Jan 2004	37	88	54
Feb 2004	23	41	17
Mar 2004	19	37	18
Apr 2004	17	35	16
May 2004	45	71	24
Jun 2004	50	163	16
Jul 2004	55	69	17
Aug 2004	57	76	9
Sep 2004	50	63	19
Oct 2004	25	28	5
Nov 2004	48	42	8
Dec 2004	20	47	19
Jan 2005	18	81	25
Feb 2005	28	79	29
Mar 2005	8	54	28
Apr 2005	11	36	18
May 2005	13	50	13
Jun 2005	16	35	12
Jul 2005	14	53	12
Aug 2005	5	35	11
Sep 2005	10	51	15
Oct 2005	24	60	16
Nov 2005	24	69	15
Dec 2005	21	59	18
Jan 2006	19	74	20
Feb 2006	20	55	17
Mar 2006	12	56	21
Apr 2006	13	36	8
May 2006	4	30	4
Jun 2006	13	34	14
Jul 2006	9	29	13
Aug 2006	9	27	6
Sep 2006	7	46	14
Oct 2006	15	56	11
Nov 2006	12	47	15
Dec 2006	6	48	14
Jan 2007	8	44	17
Feb 2007	8	46	10
Mar 2007	11	62	17
Apr 2007	41	14	4
May 2007	22	5	10
Jun 2007	20	15	2
Jul 2007	20	14	3
Aug 2007	35	14	1
Sep 2007	27	11	6
Oct 2007	21	7	4
Nov 2007	26	9	5
Dec 2007	18	7	2
Jan 2008	21	3	3
Feb 2008	23	19	10
Mar 2008	35	9	2
Apr 2008	38	9	7
May 2008	38	8	6
Jun 2008	35	9	8
Jul 2008	50	3	5
Aug 2008	72	5	6
Sep 2008	69	11	7
Oct 2008	38	4	3
Nov 2008	47	3	4
Dec 2008	24	6	7
Jan 2009	23	4	6
Feb 2009	35	2	1
Mar 2009	43	3	1
Apr 2009	42	4	3
May 2009	27	9	2
Jun 2009	22	4	2
Jul 2009	27	4	0
Aug 2009	14	3	3
Sep 2009	29	4	2
Oct 2009	35	6	2
Nov 2009	31	2	6
Dec 2009	19	3	3
Jan 2010	28	3	3
Feb 2010	26	6	6
Mar 2010	31	0	3
Apr 2010	27	6	3
May 2010	20	6	2
Jun 2010	38	5	5
Jul 2010	26	6	7
Aug 2010	25	5	9
Sep 2010	33	4	7
Oct 2010	16	2	1
Nov 2010	53	5	3
Dec 2010	33	5	1
Jan 2011	38	5	7
Feb 2011	43	1	0
Mar 2011	39	6	2
Apr 2011	21	3	3
May 2011	33	0	1
Jun 2011	40	5	3
Jul 2011	24	3	2
Aug 2011	32	4	2
Sep 2011	25	1	0
Oct 2011	27	5	3
Nov 2011	54	10	8
Dec 2011	23	21	11
Jan 2012	20	22	11
Feb 2012	24	12	2
Mar 2012	31	13	8
Apr 2012	17	22	4
May 2012	29	24	9
Jun 2012	40	34	5
Jul 2012	32	20	10
Aug 2012	23	19	9
Sep 2012	24	25	8
Oct 2012	35	29	12
Nov 2012	31	17	3
Dec 2012	28	24	9
Jan 2013	34	28	6
Feb 2013	34	37	4
Mar 2013	35	45	6
Apr 2013	35	36	13
May 2013	31	21	3
Jun 2013	15	18	1
Jul 2013	21	29	7
Aug 2013	6	14	0
Sep 2013	17	17	0
Oct 2013	45	15	5
Nov 2013	39	17	3
Dec 2013	33	17	7
Jan 2014	49	11	3
Feb 2014	50	18	4
Mar 2014	39	16	0
Apr 2014	47	18	3
May 2014	53	29	3
Jun 2014	33	11	5
Jul 2014	29	16	5
Aug 2014	18	17	3
Sep 2014	30	20	4
Oct 2014	57	41	5
Nov 2014	63	26	3
Dec 2014	44	14	4
Jan 2015	22	12	8
Feb 2015	43	9	6
Mar 2015	27	13	5
Apr 2015	33	13	5
May 2015	32	20	4
Jun 2015	40	11	5
Jul 2015	41	17	1
Aug 2015	34	12	1
Sep 2015	37	17	5
Oct 2015	23	5	3
Nov 2015	19	7	2
Dec 2015	23	9	3
Jan 2016	86	22	7
Feb 2016	17	9	2
Mar 2016	24	14	6
Apr 2016	27	7	4
May 2016	28	12	3
Jun 2016	17	13	5
Jul 2016	17	17	9
Aug 2016	18	11	1
Sep 2016	28	12	4
Oct 2016	20	37	10
Nov 2016	11	13	5
Dec 2016	15	12	3
Jan 2017	21	14	4
Feb 2017	7	21	1
Mar 2017	3	17	5
Apr 2017	2	31	2
May 2017	0	25	1
Jun 2017	20	27	10
Jul 2017	33	33	6
Aug 2017	21	17	5
Sep 2017	36	28	6
Oct 2017	42	34	6
Nov 2017	43	37	7
Dec 2017	40	38	7
Jan 2018	48	40	2
Feb 2018	31	29	6
Mar 2018	30	24	12
Apr 2018	26	16	8
May 2018	24	20	8
Jun 2018	37	25	7
Jul 2018	27	23	6
Aug 2018	21	19	5
Sep 2018	26	22	7
Oct 2018	42	38	7
Nov 2018	50	44	11
Dec 2018	32	22	11
Jan 2019	23	21	9
Feb 2019	41	24	10
Mar 2019	31	30	9
Apr 2019	37	29	17
May 2019	32	30	13
Jun 2019	27	23	16
Jul 2019	46	42	13
Aug 2019	21	19	13
Sep 2019	39	34	10
Oct 2019	29	25	12
Nov 2019	45	37	19
Dec 2019	41	42	7
Jan 2020	31	31	12
Feb 2020	28	20	12
Mar 2020	24	16	7
Apr 2020	17	15	12
May 2020	15	11	3
Jun 2020	18	16	9
Jul 2020	17	15	10
Aug 2020	15	9	3
Sep 2020	26	24	5
Oct 2020	28	20	5
Nov 2020	39	23	13
Dec 2020	37	29	8
Jan 2021	32	20	6
Feb 2021	11	7	6
Mar 2021	11	11	2
Apr 2021	16	8	5
May 2021	38	22	20
Jun 2021	12	12	10
Jul 2021	18	18	18
Aug 2021	14	14	12
Sep 2021	24	24	10
Oct 2021	25	23	20
Nov 2021	51	42	25
Dec 2021	38	30	9
Jan 2022	24	22	19
Feb 2022	31	33	11
Mar 2022	34	30	11
Apr 2022	50	38	17
May 2022	49	47	21
Jun 2022	67	74	12
Jul 2022	63	52	11
Aug 2022	59	56	5
Sep 2022	53	53	27
Oct 2022	75	74	11
Nov 2022	81	79	14
Dec 2022	64	65	9
Jan 2023	83	77	9
Feb 2023	68	69	2
Mar 2023	48	49	14
Apr 2023	40	39	9
May 2023	40	36	9
Jun 2023	40	38	8
Jul 2023	50	44	11
Aug 2023	62	57	11
Sep 2023	95	74	12
Oct 2023	83	82	8
Nov 2023	80	79	2
Dec 2023	219	31	1
Jan 2024	24	3	1
Feb 2024	105	0	0
Mar 2024	36	0	0
Total	7998	6539	2071

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