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Helicobacter pylori infection in Africa and Europe: enigma of host genetics
  1. S Hellmig,
  2. J Hampe,
  3. S Schreiber
  1. Department of General Internal Medicine, Christian-Albrechts-University Kiel, Germany
  1. Correspondence to:
    Professor S Schreiber
    Klinik für Allgemeine Innere Medizin, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstraße 12, 24105 Kiel, Germany; s.schreiber{at}mucosa.de

https://doi.org/10.1136/gut.52.12.1799

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    Helicobacter pylori infection is one of the most common bacterial infections. The prevalence varies from 25–50% in developed countries to 70–90% in the third world.1 Despite improved treatment modalities, H pylori related gastrointestinal pathology, in common with gastritis, peptic ulcers and consecutive bleeding events, gastric MALT lymphoma, or carcinoma, remains a major burden on Western health systems. In the USA, approximately four million people have active peptic ulcers and about 350 000 new cases are diagnosed each year. Four times as many duodenal ulcers as gastric ulcers are diagnosed.2 Epidemiological evidence suggests that both infection with H pylori and the consecutive development of clinically relevant pathology are influenced by genetic predisposition as only a fraction of exposed individuals develop infection and likewise a fraction …

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