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Letter
Platelet activation in patients with irritable bowel syndrome may reflect a subclinical inflammatory response
  1. A Qasim,
  2. H O’Brien,
  3. S Sebastian,
  4. M O’Sullivan,
  5. M Buckley,
  6. C O’Moran
  1. Trinity College, Dublin, Ireland
  1. Correspondence to:
    Dr A Quasim
    Gastroenterology Department, AMNCH, Tallaght, Dublin 24, Ireland; qasim{at}tcd.ie

https://doi.org/10.1136/gut.52.12.1799-a

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    We read the recent article by Houghton et al and found the results very interesting (Gut 2003;52:663–70). Their observations included higher platelet concentrations of 5-hydroxytryptamine among patients with diarrhoea predominant irritable bowel syndrome (d-IBS) compared with controls. It is interesting that a small but significant subgroup of IBS patients report onset of their symptoms after an episode of acute gastroenteritis and a role of subclinical inflammatory aetiology has been suggested for the condition.1 The role of platelets in various inflammatory conditions has previously been demonstrated but their importance in IBS remains largely unknown.2–7 We recently looked at the possibility of platelet activation in IBS patients by determining surface expression of the activation markers at baseline and after stimulation. Stimulation …

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