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Gut 52:558-562 doi:10.1136/gut.52.4.558
  • Inflammatory bowel disease

CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn’s disease

Table 3

Vienna classification of patients with Crohn’s disease according to CARD15 gene status

CARD 15 gene status
Variable Wt/Wt homozygotes (n=229) Carriers of variants (n=42) p Value
Wt, wild-type allele.
Age at onset
    <40 y 183 36 NS
    ⩾40 y 46 6
Location
    Colon 62 4
    Ileum 49 15 <0.05
    Ileocolon 112 19
    Upper GI tract 6 4
Behaviour
    Inflammatory 101 6
    Stricturing 78 20 <0.01
    Penetrating 50 17

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