Table 2
Comparison of platelet depleted plasma 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) concentrations, and turnover, between female subjects with diarrhoea predominant irritable bowel syndrome (d-IBS) with and without postprandial (pp) symptoms
| With pp symptoms (n=31) | Without pp symptoms (n=8) | Ratio with to without pp symptoms | p Value | |
|---|---|---|---|---|
| Results are adjusted geometric means (95% confidence interval). | ||||
| AUC, ratio to fasting baseline area under the postprandial concentration/time curve. | ||||
| 5-HT concn | ||||
| Fasting (nmol/l) | 29.20 | 28.57 | 1.02 (0.81,1.30) | 0.851 |
| Fed AUC | 1.78 | 1.26 | 1.41 (0.97,2.05) | 0.069 |
| Fed peak (nmol/l) | 87.59 | 54.58 | 1.61 (0.94,2.73) | 0.079 |
| 5-HIAA concn | ||||
| Fasting (nmol/l) | 28.87 | 28.87 | 1.00 (0.84,1.19) | 0.989 |
| Fed AUC | 1.43 | 1.21 | 1.18 (0.93,1.49) | 0.161 |
| Fed peak (nmol/l) | 57.32 | 44.77 | 1.28 (0.88,1.86) | 0.192 |
| Turnover (ratio 5-HIAA:5-HT) | ||||
| Fasting | 1.00 | 1.02 | 0.98 (0.88,1.09) | 0.664 |
| Fed AUC | 0.86 | 1.01 | 0.85 (0.73,1.01) | 0.058 |
| Platelet 5-HT (nmol/109 platelets) | ||||
| Fasting | 2.18 | 2.36 | 0.92 (0.76,1.13) | 0.416 |
