Incidence of gastroduodenal ulcers in patients with rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or placebo: a multicentre, randomised, double blind study

C J Hawkey; L Laine; T Simon; H Quan; S Shingo; J Evans

doi:10.1136/gut.52.6.820

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Incidence of gastroduodenal ulcers in patients with rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or placebo: a multicentre, randomised, double blind study

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	Abstract	Full	Pdf
May 2003	462	500	355
Jun 2003	202	357	169
Jul 2003	120	273	93
Aug 2003	39	117	47
Sep 2003	41	99	66
Oct 2003	29	149	48
Nov 2003	31	96	40
Dec 2003	29	83	25
Jan 2004	43	51	37
Feb 2004	42	56	38
Mar 2004	42	62	35
Apr 2004	33	56	31
May 2004	57	69	20
Jun 2004	54	98	32
Jul 2004	61	106	45
Aug 2004	59	112	44
Sep 2004	57	128	63
Oct 2004	28	92	42
Nov 2004	24	95	58
Dec 2004	22	77	31
Jan 2005	24	113	50
Feb 2005	23	113	43
Mar 2005	35	90	57
Apr 2005	9	49	22
May 2005	10	56	21
Jun 2005	18	49	30
Jul 2005	23	48	28
Aug 2005	12	38	16
Sep 2005	25	52	28
Oct 2005	17	68	20
Nov 2005	19	58	24
Dec 2005	16	40	19
Jan 2006	14	39	20
Feb 2006	12	42	12
Mar 2006	6	40	15
Apr 2006	13	39	11
May 2006	8	45	21
Jun 2006	8	45	22
Jul 2006	9	32	12
Aug 2006	8	40	7
Sep 2006	10	31	24
Oct 2006	15	35	34
Nov 2006	9	27	13
Dec 2006	3	19	7
Jan 2007	3	42	12
Feb 2007	13	34	13
Mar 2007	6	25	20
Apr 2007	16	7	9
May 2007	14	15	15
Jun 2007	17	13	19
Jul 2007	14	14	16
Aug 2007	14	31	10
Sep 2007	23	4	11
Oct 2007	19	12	8
Nov 2007	19	14	7
Dec 2007	18	4	4
Jan 2008	13	8	10
Feb 2008	17	8	11
Mar 2008	19	8	5
Apr 2008	20	13	12
May 2008	17	6	8
Jun 2008	13	10	10
Jul 2008	23	4	3
Aug 2008	17	10	4
Sep 2008	22	6	6
Oct 2008	29	10	2
Nov 2008	35	29	27
Dec 2008	30	2	7
Jan 2009	28	5	7
Feb 2009	15	9	4
Mar 2009	19	6	13
Apr 2009	6	2	8
May 2009	12	4	12
Jun 2009	6	5	6
Jul 2009	14	3	11
Aug 2009	6	1	6
Sep 2009	8	2	9
Oct 2009	11	2	5
Nov 2009	10	2	5
Dec 2009	19	1	6
Jan 2010	12	5	12
Feb 2010	7	3	7
Mar 2010	13	2	7
Apr 2010	9	1	8
May 2010	15	1	7
Jun 2010	12	3	7
Jul 2010	5	0	12
Aug 2010	23	7	5
Sep 2010	27	2	1
Oct 2010	26	10	2
Nov 2010	26	6	3
Dec 2010	15	9	2
Jan 2011	18	1	0
Feb 2011	23	8	3
Mar 2011	26	4	5
Apr 2011	25	0	1
May 2011	25	5	1
Jun 2011	23	2	4
Jul 2011	27	8	0
Aug 2011	11	0	0
Sep 2011	28	6	2
Oct 2011	18	4	1
Nov 2011	19	16	1
Dec 2011	14	38	10
Jan 2012	10	40	3
Feb 2012	11	53	7
Mar 2012	7	46	6
Apr 2012	10	30	11
May 2012	10	36	7
Jun 2012	12	21	12
Jul 2012	27	45	16
Aug 2012	11	31	13
Sep 2012	15	29	9
Oct 2012	16	32	17
Nov 2012	24	16	18
Dec 2012	18	18	12
Jan 2013	19	10	11
Feb 2013	19	24	7
Mar 2013	23	13	12
Apr 2013	21	23	11
May 2013	17	17	9
Jun 2013	11	18	11
Jul 2013	11	14	9
Aug 2013	8	14	4
Sep 2013	15	20	8
Oct 2013	14	15	1
Nov 2013	10	20	13
Dec 2013	12	25	9
Jan 2014	10	44	20
Feb 2014	4	31	13
Mar 2014	9	24	7
Apr 2014	11	43	8
May 2014	7	49	4
Jun 2014	11	42	6
Jul 2014	23	38	8
Aug 2014	9	28	12
Sep 2014	5	34	8
Oct 2014	9	47	25
Nov 2014	1	34	15
Dec 2014	10	29	5
Jan 2015	16	25	7
Feb 2015	9	25	10
Mar 2015	16	30	10
Apr 2015	6	24	10
May 2015	9	40	15
Jun 2015	10	52	18
Jul 2015	6	28	6
Aug 2015	9	32	11
Sep 2015	9	29	16
Oct 2015	7	12	6
Nov 2015	3	24	10
Dec 2015	6	40	13
Jan 2016	6	24	8
Feb 2016	8	17	11
Mar 2016	8	7	10
Apr 2016	13	5	16
May 2016	7	11	4
Jun 2016	14	16	6
Jul 2016	4	52	14
Aug 2016	8	12	11
Sep 2016	14	10	5
Oct 2016	13	19	6
Nov 2016	11	14	2
Dec 2016	7	13	4
Jan 2017	10	21	9
Feb 2017	7	6	8
Mar 2017	2	16	5
Apr 2017	0	20	3
May 2017	1	34	9
Jun 2017	6	20	4
Jul 2017	20	18	10
Aug 2017	17	14	12
Sep 2017	15	13	9
Oct 2017	20	20	11
Nov 2017	24	22	7
Dec 2017	16	16	10
Jan 2018	11	11	3
Feb 2018	17	13	15
Mar 2018	21	21	13
Apr 2018	17	17	17
May 2018	24	23	2
Jun 2018	32	33	6
Jul 2018	30	30	3
Aug 2018	22	22	7
Sep 2018	24	24	3
Oct 2018	47	45	8
Nov 2018	53	49	12
Dec 2018	42	42	2
Jan 2019	54	51	12
Feb 2019	54	45	14
Mar 2019	61	45	22
Apr 2019	17	17	7
May 2019	15	13	10
Jun 2019	18	16	21
Jul 2019	29	26	17
Aug 2019	16	16	13
Sep 2019	9	9	13
Oct 2019	10	10	10
Nov 2019	20	19	11
Dec 2019	19	15	8
Jan 2020	37	37	5
Feb 2020	24	18	14
Mar 2020	11	7	8
Apr 2020	12	10	7
May 2020	10	8	9
Jun 2020	13	11	10
Jul 2020	10	10	4
Aug 2020	6	6	6
Sep 2020	23	21	14
Oct 2020	31	27	13
Nov 2020	17	13	10
Dec 2020	23	16	10
Jan 2021	11	11	4
Feb 2021	10	10	8
Mar 2021	19	13	3
Apr 2021	12	10	7
May 2021	6	6	3
Jun 2021	15	15	9
Jul 2021	10	10	8
Aug 2021	6	6	8
Sep 2021	11	10	7
Oct 2021	11	9	16
Nov 2021	13	10	22
Dec 2021	16	14	6
Jan 2022	12	13	10
Feb 2022	9	9	3
Mar 2022	15	16	8
Apr 2022	39	33	11
May 2022	34	31	27
Jun 2022	21	21	10
Jul 2022	16	15	4
Aug 2022	22	21	10
Sep 2022	25	27	11
Oct 2022	37	31	20
Nov 2022	12	12	5
Dec 2022	19	16	9
Jan 2023	10	10	4
Feb 2023	28	28	1
Mar 2023	13	7	2
Apr 2023	9	5	5
May 2023	2	2	6
Jun 2023	9	9	0
Jul 2023	20	9	4
Aug 2023	6	6	2
Sep 2023	13	11	3
Oct 2023	15	10	10
Nov 2023	12	12	4
Dec 2023	62	1	1
Jan 2024	47	0	0
Feb 2024	34	0	0
Mar 2024	178	2	1
Total	5408	7507	3641

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