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Expression of thiopurine methyltransferase in South Asians
  1. E Tsironi,
  2. M Browne,
  3. D S Rampton,
  4. A B Ballinger
  1. Academic Department of Adult and Paediatric Gastroenterology, Barts and the London, Queen Mary’s School of Medicine and Dentistry, and Department of Clinical Biochemistry, Barts and the London NHS Trust, London, UK.
  1. Correspondence to:
    Dr E Tsironi, Barts and the London NHS Trust, London E1 1BB, UK;
    etsironi{at}yahoo.com

https://doi.org/10.1136/gut.52.6.914-a

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    Azathioprine and its metabolite 6-mercaptopurine (6-MP) are widely used in the treatment of Crohn’s disease, ulcerative colitis, autoimmune hepatitis, and a range of other inflammatory and autoimmune diseases, as well as for prevention of transplant rejection. Thiopurine methyltransferase (TPMT) converts 6-MP to 6-methylMP.1,2 Deficiency of its expression predisposes treated patients to bone marrow depression; …

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