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Liver tolerance mediated by antigen presenting cells: fact or fiction?
  1. A H Lau1,
  2. A de Creus2,
  3. L Lu2,
  4. A W Thomson1
  1. 1Department of Surgery and Department of Immunology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
  2. 2Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
  1. Correspondence to:
    Dr A Thomson, Departments of Surgery and Immunology, University of Pittsburgh Medical Center, W1544 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15213, USA;
    thomsonaw{at}msx.upmc.edu

Abstract

Possible mechanisms by which liver antigen presenting cells (APC) may facilitate tolerance induction are discussed. Tolerance may be facilitated by a distinctive combination of factors, linked to the unique anatomical and microenvironmental features of the liver.

  • liver tolerance
  • antigen presenting cells
  • Ag, antigen
  • MHC, major histocompatibility complex
  • APC, antigen presenting cells
  • DC, dendritic cells
  • LSEC, liver sinusoidal endothelial cells
  • KC, Kupffer cells
  • IL, interleukin
  • TGF, transforming growth factor
  • PG, prostaglandin
  • NK, natural killer
  • TNF, tumour necrosis factor
  • Th, T helper
  • Treg, regulatory T cells
  • IFN, interferon
  • CTLA4Ig, cytotoxic T lymphocyte Ag 4 immunoglobulin

https://doi.org/10.1136/gut.52.8.1075

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