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Gut 52:1211-1214 doi:10.1136/gut.52.8.1211
  • Case report

Small bowel neoplasia in coeliac disease

  1. S D Rampertab,
  2. K A Forde,
  3. P H R Green
  1. Columbia University College of Physicians and Surgeons, New York, USA
  1. Correspondence to:
    Dr P H R Green, Columbia University College of Physicians and Surgeons, 161 Fort Washington Ave, Room 645, New York 10032, USA;
    pg11{at}columbia.edu
  • Accepted 18 March 2003

Abstract

There is an increased risk of small bowel adenocarcinoma in patients with coeliac disease compared with the normal population. It has been suggested that adenocarcinoma of the small intestine in coeliac disease arises through an adenoma-carcinoma sequence but there has been only one reported case of a small bowel adenoma in a patient with coeliac disease. We report three additional cases of a small bowel adenoma in the setting of coeliac disease. In addition, four cases of small bowel adenocarcinoma are also reported, one of which was found adjacent to a jejunal villous adenoma. These cases emphasise the risk of the development of small bowel neoplasia for patients with coeliac disease and support the concept that small bowel adenocarcinoma in coeliac disease arises from adenomas.

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