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The COX controversy
New dogmas or old?
  1. B J R Whittle
  1. William Harvey Research Institute, Barts and The London, Queen Mary’s School of Medicine, Charterhouse Square, London EC1M 6BQ, UK; b.j.whittle{at}qmul.ac.uk

Abstract

Recent experimental studies may undermine our understanding of the gastrointestinal side effects of non-steroidal anti-inflammatory drugs and cast a shadow on the original concept that underpins the development of the recent addition to the clinical anti-inflammatory armamentarium, the COX-2 selective inhibitors. But is this just a passing cloud or a total eclipse of the COX theory?

  • cyclooxygenase 1
  • cyclooxygenase 2
  • non-steroidal anti-inflammatory drugs
  • gastric injury
  • enteropathy
  • NSAIDs, non-steroidal anti-inflammatory drugs
  • NO, nitric oxide
  • iNOS, inducible nitric oxide synthase
  • AS, ankylosing spondylitis

https://doi.org/10.1136/gut.52.9.1379

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    Linked Articles

    • The COX controversy
      NSAIDs: the Emperor’s new dogma?
      I Bjarnason K Takeuchi R Simpson
      Gut 2003; 52 1376-1378 Published Online First: 11 Aug 2003. doi: 10.1136/gut.52.9.1376