Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases

M D Crabtree; C Fletcher; M Churchman; S V Hodgson; K Neale; R K S Phillips; I P M Tomlinson

doi:10.1136/gut.2003.015586

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Colon cancer

Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases

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	Abstract	Full	Pdf
Jan 2004	60	105	69
Feb 2004	32	105	64
Mar 2004	23	73	42
Apr 2004	37	68	40
May 2004	56	73	21
Jun 2004	39	130	24
Jul 2004	57	93	22
Aug 2004	42	68	31
Sep 2004	33	48	10
Oct 2004	20	56	11
Nov 2004	27	36	7
Dec 2004	20	32	11
Jan 2005	32	36	13
Feb 2005	23	34	15
Mar 2005	38	70	37
Apr 2005	3	31	19
May 2005	17	31	25
Jun 2005	13	30	19
Jul 2005	8	27	22
Aug 2005	5	23	21
Sep 2005	11	35	23
Oct 2005	10	31	21
Nov 2005	11	30	13
Dec 2005	3	21	8
Jan 2006	7	24	13
Feb 2006	8	27	18
Mar 2006	8	28	19
Apr 2006	4	25	12
May 2006	3	20	11
Jun 2006	2	18	15
Jul 2006	8	16	13
Aug 2006	0	10	7
Sep 2006	3	10	12
Oct 2006	6	13	6
Nov 2006	4	10	4
Dec 2006	1	15	10
Jan 2007	2	18	13
Feb 2007	2	16	9
Mar 2007	3	15	11
Apr 2007	9	9	5
May 2007	3	4	6
Jun 2007	4	4	5
Jul 2007	2	5	3
Aug 2007	3	6	9
Sep 2007	6	2	3
Oct 2007	2	1	3
Nov 2007	11	7	10
Dec 2007	6	1	0
Jan 2008	5	1	2
Feb 2008	8	2	3
Mar 2008	3	1	0
Apr 2008	13	0	2
May 2008	8	2	3
Jun 2008	9	2	3
Jul 2008	20	3	7
Aug 2008	10	2	2
Sep 2008	7	6	4
Oct 2008	6	1	1
Nov 2008	7	0	0
Dec 2008	8	4	3
Jan 2009	8	2	2
Feb 2009	6	5	7
Mar 2009	26	4	4
Apr 2009	21	0	1
May 2009	6	3	1
Jun 2009	6	2	2
Jul 2009	8	1	2
Aug 2009	5	0	2
Sep 2009	3	1	2
Oct 2009	13	4	4
Nov 2009	6	1	1
Dec 2009	20	0	1
Jan 2010	4	1	3
Feb 2010	6	1	0
Mar 2010	4	4	2
Apr 2010	23	2	2
May 2010	7	2	0
Jun 2010	18	0	2
Jul 2010	6	1	4
Aug 2010	8	2	1
Sep 2010	1	1	2
Oct 2010	5	2	1
Nov 2010	9	1	1
Dec 2010	5	4	5
Jan 2011	4	1	0
Feb 2011	3	1	0
Mar 2011	10	6	8
Apr 2011	6	1	2
May 2011	6	4	2
Jun 2011	8	0	2
Jul 2011	5	0	1
Aug 2011	4	1	1
Sep 2011	11	1	1
Oct 2011	8	2	2
Nov 2011	9	3	2
Dec 2011	6	5	4
Jan 2012	10	4	9
Feb 2012	4	3	6
Mar 2012	4	2	4
Apr 2012	6	3	9
May 2012	10	5	8
Jun 2012	7	4	8
Jul 2012	2	8	5
Aug 2012	7	5	9
Sep 2012	5	4	8
Oct 2012	6	3	8
Nov 2012	13	7	4
Dec 2012	15	19	5
Jan 2013	23	5	1
Feb 2013	28	15	5
Mar 2013	8	4	5
Apr 2013	11	8	9
May 2013	5	6	7
Jun 2013	4	9	5
Jul 2013	4	0	1
Aug 2013	5	4	7
Sep 2013	7	4	0
Oct 2013	16	6	0
Nov 2013	12	6	6
Dec 2013	4	4	7
Jan 2014	5	4	13
Feb 2014	6	4	4
Mar 2014	19	9	2
Apr 2014	6	4	1
May 2014	3	9	4
Jun 2014	4	7	3
Jul 2014	17	10	5
Aug 2014	15	8	5
Sep 2014	9	5	6
Oct 2014	3	3	6
Nov 2014	7	2	2
Dec 2014	1	2	1
Jan 2015	4	0	1
Feb 2015	4	2	4
Mar 2015	13	5	3
Apr 2015	6	5	2
May 2015	7	3	2
Jun 2015	5	13	4
Jul 2015	7	1	0
Aug 2015	6	1	0
Sep 2015	7	6	3
Oct 2015	8	2	0
Nov 2015	4	1	1
Dec 2015	3	3	2
Jan 2016	8	1	1
Feb 2016	6	6	0
Mar 2016	4	2	3
Apr 2016	3	5	11
May 2016	9	2	7
Jun 2016	3	4	4
Jul 2016	6	11	2
Aug 2016	10	7	3
Sep 2016	13	6	6
Oct 2016	16	3	9
Nov 2016	7	4	0
Dec 2016	4	9	0
Jan 2017	11	6	4
Feb 2017	4	5	1
Mar 2017	0	12	2
Apr 2017	0	18	0
May 2017	0	16	2
Jun 2017	2	10	0
Jul 2017	19	19	4
Aug 2017	15	15	2
Sep 2017	6	6	2
Oct 2017	15	15	1
Nov 2017	12	10	2
Dec 2017	8	8	0
Jan 2018	8	8	0
Feb 2018	11	7	2
Mar 2018	11	9	0
Apr 2018	13	13	1
May 2018	12	12	4
Jun 2018	26	26	4
Jul 2018	12	12	0
Aug 2018	10	10	2
Sep 2018	8	8	0
Oct 2018	3	3	0
Nov 2018	5	5	1
Dec 2018	7	7	2
Jan 2019	3	3	1
Feb 2019	6	5	2
Mar 2019	5	5	5
Apr 2019	5	5	4
May 2019	3	3	7
Jun 2019	4	4	11
Jul 2019	4	4	13
Aug 2019	7	5	3
Sep 2019	4	4	4
Oct 2019	2	2	3
Nov 2019	6	6	5
Dec 2019	9	9	4
Jan 2020	3	3	3
Feb 2020	3	3	2
Mar 2020	6	6	6
Apr 2020	4	4	2
May 2020	2	2	4
Jun 2020	8	8	3
Jul 2020	11	6	2
Aug 2020	10	10	6
Sep 2020	10	10	0
Oct 2020	12	12	4
Nov 2020	4	4	3
Dec 2020	9	9	6
Jan 2021	9	9	2
Feb 2021	17	15	4
Mar 2021	11	11	4
Apr 2021	6	6	4
May 2021	9	9	10
Jun 2021	6	6	1
Jul 2021	13	13	10
Aug 2021	5	5	5
Sep 2021	1	1	5
Oct 2021	6	3	23
Nov 2021	7	7	14
Dec 2021	5	5	3
Jan 2022	12	9	3
Feb 2022	3	3	5
Mar 2022	12	10	6
Apr 2022	20	12	6
May 2022	18	18	16
Jun 2022	21	19	9
Jul 2022	11	9	0
Aug 2022	31	31	6
Sep 2022	16	15	23
Oct 2022	22	20	8
Nov 2022	11	9	4
Dec 2022	9	8	3
Jan 2023	4	4	1
Feb 2023	39	37	0
Mar 2023	5	3	1
Apr 2023	8	8	5
May 2023	2	2	5
Jun 2023	6	5	4
Jul 2023	6	7	8
Aug 2023	6	4	12
Sep 2023	5	5	16
Oct 2023	16	14	5
Nov 2023	7	7	2
Dec 2023	29	0	0
Jan 2024	40	0	0
Feb 2024	11	0	0
Mar 2024	112	1	1
Total	2544	2732	1541

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