Article Text
Leading article
Fibrosis progression in chronic hepatitis C virus infection
Abstract
Chronic hepatitis C virus infection is typically characterised by slowly progressive hepatic fibrosis. However, it is recognised that some patients do not progress while others rapidly develop significant fibrosis. Here, we review studies that have assessed factors that could influence this rate of fibrotic progression.
- hepatitis C virus
- fibrosis
- HCV, hepatitis C virus
- HSC, hepatic stellate cell
- IR, insulin resistance
- CHC, chronic hepatitis C
- TNF, tumour necrosis factor
- PPAR, peroxisome proliferator activated receptor
- IFN-γ, interferon γ
- TGF-β, transforming growth factor β