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Menetrier disease
  1. A Cardenas,
  2. C Kelly
  1. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
  1. Correspondence to:
    Dr A Cardenas
    Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis St-Suite 8E, Boston, Massachusetts 02215, USA; acardenabidmc.harvard.edu

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QUESTION

A 31 year old man presented with nausea, epigastric discomfort, and weakness. He reported coffee ground emesis, melena, and had a history of iron deficiency anaemia of two years requiring oral iron supplementation and repeated blood transfusions. He had no other significant medical, surgical, or family history. Computed tomography scan of the abdomen revealed marked diffuse thickening of the gastric walls without any lymphadenopathy. Upper gastrointestinal endoscopy revealed giant folds with a polypoid appearance in the body and fundus of the stomach (fig 1). Mucosal biopsies of the fundus, body, and antrum were obtained. Stains for Helicobacter pylori were negative. The history and histological findings of this case are consistent with what disease?

Figure 1

Upper gastrointestinal endoscopy of the stomach revealing giant folds with a polypoid appearance in the body and fundus.

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