Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications
- Department of Clinical and Experimental Medicine, Clinica Medica 5, University of Padova, Padova, Italy
- Correspondence to:
Dr L Benvegnù
Department of Clinical and Experimental Medicine, Clinica Medica 5°, University of Padova, Via Giustiniani, 2-35128, Padova, Italy;
- Accepted 12 November 2003
Background and aims: The natural history of initially compensated cirrhosis due to hepatitis B (HBV) or hepatitis C (HCV) virus is only partially defined. We have investigated morbidity and mortality rates and the hierarchy of complications in compensated viral cirrhosis over a long follow up period.
Patients and Methods: A cohort of Italian patients with initially compensated cirrhosis of viral aetiology were followed up at six monthly intervals with laboratory tests to identify major complications (ascites, gastrointestinal bleeding, portal-systemic encephalopathy, hepatocellular carcinoma) and to assess the progression of Child’s stage and mortality rate due to liver related causes.
Results: Between 1986 and 1996, 312 patients (43 HBV positive, 254 HCV positive, and 15 HBV and HCV coinfected) were included. During a median follow up of 93 (range 14–194) months, 102 (32.6%) patients developed at least one complication (HCV positive 31.1%; HBV positive 34.8%; HBV and HCV coinfected 53.3%). Overall, the most frequent complication was hepatocellular carcinoma which occurred in 65 (20.8%) cases, followed by ascites (61 cases, 19.5%), gastrointestinal bleeding (14 cases, 4.5%), and portal-systemic encephalopathy (six cases, 1.9%). Progression of Child’s stage was observed in 62 patients (19.8%). Death from liver disease occurred in 58 (18.6%) cases and in 70.7% this was due to hepatocellular carcinoma. Hepatocellular carcinoma was the first complication to develop in 59 cases and represented the most frequent first complication in both HCV and HBV/ HCV related cirrhosis.
Conclusions: These results indicate significant morbidity and mortality during the first decade after diagnosis of compensated cirrhosis due to HBV and/or HCV, and identify hepatocellular carcinoma as the most frequent and life threatening complication, particularly in HCV positive cases.
- HBV, hepatitis B virus
- HCV, hepatitis C virus
- HDV, hepatitis D virus
- US, ultrasound
- CT, computed tomography
- MR, magnetic resonance
- HBsAg, hepatitis B surface antigen
- ELISA, enzyme linked immunosorbent assay
- HCC, hepatocellular carcinoma
- IFN, interferon