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Gut 53:1020-1023 doi:10.1136/gut.2003.027086
  • Liver

Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: role of insulin resistance

Table 1

 Comparison of biochemical and demographic parameters between hypertensive patients and control subjects

Hypertensives (n = 55) Controls (n = 55) p Value
Data are mean (SD); p values refer to t test for paired data.
HDL, high density lipoprotein; AST, aspartate transaminase; ALT, alanine transaminase; γGT, gamma glutamyl transpeptidase. Insulin resistance was estimated as the homeostasis model assessment index (see methods).
Upper reference limits are 37 IU/l for AST, 40 IU/l for ALT, and 50 IU/l for γGT, in our laboratory.
Fasting serum insulin (μIU/ml) 9.67 (6.50) 7.13 (2.66) 0.011
Fasting serum glucose (mg/l) 91.9 (11.7) 87.5 (10.1) 0.064
Insulin resistance (%) 2.27 (1.81) 1.56 (0.70) 0.011
Body mass index (kg/m2) 24.9 (3.0) 24.0 (2.2) 0.073
Serum total cholesterol (mg/dl) 207.3 (31.0) 195.4 (41.1) 0.077
Serum HDL cholesterol (mg/dl) 48.8 (11.5) 48.8 (11.7) 0.983
Serum triglycerides (mg/dl) 110.6 (55.3) 107.4 (51.1) 0.619
AST (IU/l) 19.9 (4.9) 18.9 (4.2) 0.232
ALT (IU/l) 22.0 (8.2) 20.4 (7.5) 0.222
γGT (IU/l) 23.6 (13.6) 25.5 (19.3) 0.545
Age (years) 52.7 (10.0) 52.5 (10.0) 0.219

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