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Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin
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- Published on: 18 April 2016
- Published on: 18 April 2016Acylated ghrelin stimulates food intake, but des-acylated ghrelin has no effectShow More
Dear Editor,
We were interested to read the article of Asakawa et al. Gut 2005;54:18-24 which reported that ICV and peripheral administration of des -acylated ghrelin inhibited food intake in mice in the fasted state. Acylated ghrelin (AG) has a unique biological structure with an acyl side chain on the 3rd amino acid residue. AG is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a) [1] and...
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