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Antiapoptosis action of aged garlic extract (AGE) protects epithelial cells from methotrexate induced injury
  1. T Li1,
  2. K Ito1,
  3. S-i Sumi2,
  4. T Fuwa2,
  5. T Horie3
  1. 1Graduate School of Pharmaceutical Sciences, Chiba University, Japan
  2. 2Central Research Laboratories, Wakunaga Pharmaceutical Company, Japan
  3. 3Graduate School of Pharmaceutical Sciences, Chiba University, Japan
  1. Correspondence to:
    Dr T Horie
    Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan; horietop.chiba-u.ac.jp

https://doi.org/10.1136/gut.2005.076489

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    Methotrexate (MTX) is widely used not only as a chemotherapeutic agent for the treatment of many cancers but also as an anti-inflammatory and immunosuppressive agent. MTX treatment is often accompanied by side effects such as nausea, vomiting, diarrhoea, stomatitis, gastrointestinal ulceration, and mucositis. The therapeutic use of MTX has been limited by its toxicity for proliferating cells, especially the rapidly dividing cells of intestinal crypts. MTX inhibited intestinal epithelial proliferation and induced apoptosis in the small intestinal crypts.1,2 However, there is little effective treatment to reduce the MTX induced gastrointestinal toxicity.

    Garlic (Allium sativum) has various biological properties such as antimicrobial and antithrombotic activities, immune system enhancement, and antitumour potential.3 Aged garlic extract (AGE) and its constituents have been shown to prevent oxidative injury in …

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    • Conflict of interest: None declared.