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Gut 54:503-509 doi:10.1136/gut.2003.034165
  • Inflammatory bowel disease

Activation of nuclear factor κB in colonic mucosa from patients with collagenous and ulcerative colitis

Table 2

 Immunohistochemical staining: scoring of nuclear factor κB staining according to cell type

Material Epithelial cells Macrophages (CD68 positive cells) Fibroblasts (vimentin positive cells)
Percentage of stained cells was scored as follows: 0, no nuclear staining; +, nuclear staining in 1–10% of the cell type under examination; ++, nuclear staining in 11–25% of the cell type under examination; +++, nuclear staining in more than 25% of the cell type examined.
In uninflamed bowel, weak but distinct and focal staining was observed in epithelial cells (0/+). In collagenous colitis, only sporadic (<1%) CD68 positive cells were seen with nuclear factor κB staining, with an overall score of zero (0).
Uninflamed bowel 0/+ 0 0
Collagenous colitis +++ 0 0
Ulcerative colitis ++ + 0

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