Table 4
Prognostic factor analysis on the main end point variables—endoscopic healing of erosive reflux disease (ERD) by week 8 and complete heartburn resolution in non-erosive reflux disease (NERD) patients by week 4
| ERD | NERD | ||||
|---|---|---|---|---|---|
| n* | % Healed | p Value | n† | % CHR | |
| BMI, body mass index; BO, Barrett’s oesophagus; Hp, Helicobacter pylori; CHR, complete heartburn resolution. | |||||
| n*, patients with post-treatment endoscopic healing assessment; n†, patients with post-treatment heartburn assessment. | |||||
| The prognostic analysis for NERD at the last visit showed p>0.05 in all cases except for Hp where p = 0.03. | |||||
| Prognostic factor | 2867 | 87.7 | 2790 | 64.8 | |
| LA classification | N/A | N/A | |||
| A/B | 2312 | 90.3 | <0.0001 v C/D | ||
| C/D | 555 | 76.9 | |||
| Sex | |||||
| Male | 1743 | 87.2 | NS | 1253 | 65.0 |
| Female | 1124 | 88.5 | 1537 | 64.7 | |
| Age (y) | |||||
| <60 | 1710 | 87.5 | NS | 1742 | 64.2 |
| ⩾60 | 1157 | 88.0 | 1048 | 65.8 | |
| BMI classification | NS | ||||
| <30 | 2240 | 87.7 | 2261 | 64.8 | |
| 30+ | 615 | 87.8 | 519 | 64.7 | |
| BO diagnosed | |||||
| No | 2450 | 90.3 | 2724 | 64.9 | |
| Yes | 417 | 72.4 | <0.0001 v “No” | 66 | 60.6 |
| Hp positive baseline | |||||
| No | 2157 | 87.0 | 1949 | 63.7 | |
| Yes | 665 | 90.7 | NS | 791 | 68.1 |
